Recombinant Mouse Kinesin heavy chain isoform 5A (Kif5a), partial

說明書

中文名稱：

小鼠Kif5a重組蛋白
貨號：

012341MO
規(guī)格：
其他：

產(chǎn)品詳情
產(chǎn)品評價
靶點詳情

產(chǎn)品詳情

Uniprot No.：

P33175
基因名：

Kif5a
別名：

Kif5a; Kiaa4086; Kif5; Nkhc1Kinesin heavy chain isoform 5A; Kinesin heavy chain neuron-specific 1; Neuronal kinesin heavy chain; NKHC
免疫原種屬：

Mus musculus (Mouse)
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
應(yīng)用說明：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
儲存條件：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation.
基因功能參考文獻(xiàn)：
1. Klf5 contributes to adult mouse corneal epithelial homeostasis by promoting (1) permeability barrier function through upregulation of Tjp1, Gkn1, Dsg1a, Lama3, and Lamb1, and (2) basal cell proliferation through upregulation of cyclin-D1 and suppression of phospho(Ser-10) p27/Kip1 PMID: 28910443
2. Results from the present study reveal a new system mediated by kinesin-1 sorting in axons that differentially controls stability of arbor terminals. PMID: 27505885
3. Data suggest that KIF5 regulates gephyrin sorting by a mechanism that involves GSK3 activity. PMID: 25701174
4. KIF5-SNPH interaction mediates activity-induced immobilization of axonal mitochondria. PMID: 23857772
5. Found a role of KIF5A in process outgrowth and axonal transport of mitochondria, affecting motor neurons more severely than sensory neurons. PMID: 22466687
6. Expression of Kif5a in the mouse prefrontal cortex is modulated by a sequence variant (B2 SINE indel) in the 3' UTR of Comt (catechol-O-methyltransferase). PMID: 20808911
7. Data suggest that kinesin-1A is the principal anterograde motor for neurofilaments, that there may be functional redundancy among isoforms in neurofilament transport, and that anterograde and retrograde neurofilament motors are tightly coordinated. PMID: 19812246
8. assessement of the kinetics of the dystrobrevin-Kif5A interaction suggesting that the tertiary structure of dystrobrevin may play a role in regulating its interaction with Kif5a PMID: 16288919
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亞細(xì)胞定位：

Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton. Perikaryon.
蛋白家族：

TRAFAC class myosin-kinesin ATPase superfamily, Kinesin family, Kinesin subfamily
數(shù)據(jù)庫鏈接：

KEGG: mmu:16572

STRING: 10090.ENSMUSP00000096775

UniGene: Mm.30355