Recombinant Human Cytokine receptor common subunit beta (CSF2RB), partial

說明書

中文名稱：

Recombinant Human Cytokine receptor common subunit beta(CSF2RB),partial
貨號：

006047HU
規格：
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

P32927
基因名：

CSF2RB
別名：

Beta-C; CD131; CDw131; Colony stimulating factor 2 receptor beta; Colony stimulating factor 2 receptor beta low affinity (granulocyte macrophage) ; Common beta chain; Csf2rb; Cytokine receptor common beta chain; Cytokine receptor common beta chain precursor (CDw131 antigen) ; Cytokine receptor common subunit beta; GM CSF/IL 3/IL 5 receptor common beta chain; GM-CSF/IL-3/IL-5 receptor common beta subunit; granulocyte-macrophage colony-stimulating factor receptor, beta; IL3RB; IL3RB_HUMAN; IL5RB; Interleukin 3 receptor, beta; Interleukin 3 receptor/granulocyte macrophage colony stimulating factor 3 receptor beta (high affinity); Interleukin 5 receptor, beta; SMDP5; stimulating factor 3 receptor, beta (high affinity)
免疫原種屬：

Homo sapiens (Human)
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
應用說明：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
儲存條件：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.
基因功能參考文獻：
1. SYK mediates the actions of EPO and GM-CSF and coordinates with TGF-beta in erythropoiesis. PMID: 28131718
2. Exome sequencing identified candidate variants, including a missense mutation in DUOX2 that impaired its function and a frameshift mutation in CSF2RB that was associated with Crohn's Disease in an independent cohort of Ashkenazi Jewish individuals. PMID: 27373512
3. In a genetic analysis of Ashkenazi Jewish individuals, we associated Crohn's Disease with a frameshift mutation in CSF2RB. Intestinal monocytes from carriers of this mutation had reduced responses to granulocyte-macrophage colony-stimulating factor, providing an additional mechanism for alterations to the innate immune response in individuals with Crohn's Disease. PMID: 27377463
4. VitD-mediated stimulation of GC anti-inflammatory affects human monocytes in a process involving GM-CSF and MED14 PMID: 23572530
5. These data suggest that expression of GM-CSF and its receptor subunits by colon tumors may be a useful marker for prognosis PMID: 23108143
6. JAK kinase binding to betac requires the presence of three critical betac lysine residues, and this binding event is essential for receptor ubiquitination, endocytosis, and signaling. PMID: 21965659
7. Over expression of IL-3Ralpha and truncated mutation of hbetac may be involved in proliferation and differentiation block in NB4 cells. PMID: 21176354
8. Granulocyte/macrophage colony-stimulating factor causes a paradoxical increase in the BH3-only pro-apoptotic protein Bim in human neutrophils PMID: 20705940
9. The results of the study support CSF2RB as a risk factor common to both schizophrenia and major depression in the Chinese Han population. PMID: 21247258
10. Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations [case report] PMID: 21205713
11. the up-regulation of IL-3Rbeta expression may contribute to the maintenance of proliferation rather than cell differentiation. PMID: 21207215
12. The beta1 integrin-interacting domain in the extracellular domain of IL-3Rbeta was identified. A fragment of a protein corresponding to domain 4 of IL-3Rbeta prevented IL-3-mediated arterial morphogenesis and endothelial cell migration. PMID: 20802515
13. the domain 1 D-E loop disulfide of hbetac and beta(IL-3) have roles in maintaining the precise positions of ligand-binding residues necessary for normal high affinity binding and signaling PMID: 20516062
14. Two different modes of beta c binding are utilized in the presence of the hIL-3R alpha isoforms. PMID: 20472554
15. hGM-CSF activation of hGM/beta(c)with or w/o the hbeta(c) subunit, promoted primitive phenotype maintenance, indicating that the hGM Ralpha chain cytosolic domain is needed for differentiation mediated by the hGM Ralpha, beta(c) receptor complex. PMID: 12384414
16. JAK2 activation mediates cross-talk between extracellular domain mutants of the beta-subunit of the GM-CSF receptor and EpoR PMID: 12488507
17. Interleukin-3 binding to the human betac receptor involves functional epitopes formed by domains 1 and 4 of different protein chains PMID: 15060062
18. A minor improvement in resolution has given a clearer indication of the position and stabilization of the key residues Tyr15, Phe79, Tyr347, His349, Ile350 and Tyr403 in the elbow region between domain 1 and domain 4 of the dimer-related molecule. PMID: 16754968
19. These results suggest that the JAK1-JH7-3 domains are required for interleukin-3 receptor common beta subunit interaction and abolish wild type JAK1 and JAK2-mediated signaling. PMID: 16767694
20. This study found that several markers (rs2072707, rs2284031 and rs909486)of csf2rb showed sex-specific and family history-dependent associations with schizophrenia. PMID: 17667962
21. The dynamic role of the common signaling subunit beta c is to prevent IL5alpha and GM-CSF ligand-receptor complexes from rapidly dissociating. PMID: 18294864
22. The interaction between intercellular adhesion molecule 1 (ICAM-1) and the GM-CSF receptor is essential for GM-CSF-induced eosinophil activation and survival. PMID: 18322230
23. IL-5-induced effects on betac assembly in the presence of nontagged IL-5Ralpha provide direct evidence that IL-5 can cause higher order rearrangements of betac homo-oligomers PMID: 18326494
24. Ligand-binding and receptor activation are not critically dependent on individual N-glycosylation sites within the IL-3- and IL-5-receptor common beta-subunit. PMID: 18374598
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相關疾病：

Pulmonary surfactant metabolism dysfunction 5 (SMDP5)
亞細胞定位：

Membrane; Single-pass type I membrane protein.
蛋白家族：

Type I cytokine receptor family, Type 4 subfamily
數據庫鏈接：

HGNC: 2436

OMIM: 138981

KEGG: hsa:1439

STRING: 9606.ENSP00000384053

UniGene: Hs.592192