ZNF462 Antibody, Biotin conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ZNF462 Polyclonal antibody
Uniprot No.：

Q96JM2
基因名：

ZNF462
別名：

DKFZp686B2325 antibody; DKFZp762N2316 antibody; FLJ14960 antibody; FLJ45904 antibody; KIAA1803 antibody; RP11-508N12.1 antibody; Zinc finger protein 462 antibody; ZN462_HUMAN antibody; ZNF462 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Zinc finger protein 462 protein (2223-2506AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Zinc finger nuclear factor involved in transcription by regulating chromatin structure and organization. Involved in the pluripotency and differentiation of embryonic stem cells by regulating SOX2, POU5F1/OCT4, and NANOG. By binding PBX1, prevents the heterodimerization of PBX1 and HOXA9 and their binding to DNA. Regulates neuronal development and neural cell differentiation.
基因功能參考文獻：
1. In the current study we describe a patient with a syndromic form of autism spectrum disorder and intellectual disability characterized by metopic craniosynostosis, ptosis and corpus callosum dysgenesis most likely caused by ZNF462 haploinsufficiency. The possible contribution of the disruption of KLF12 by one of the translocation breakpoints remains unclear. PMID: 29427787
2. Loss of function variants in ZNF462 were identified in patients with ptosis, metopic ridging, craniosynostosis, dysgenesis of the corpus callosum, and developmental delay. PMID: 28513610
3. Zinc finger protein 462 (ZNF462) is the first human O-GlcNAc-6-phosphate modified protein. PMID: 22826440
亞細胞定位：

Nucleus.
數據庫鏈接：

HGNC: 21684

OMIM: 617371

KEGG: hsa:58499

STRING: 9606.ENSP00000277225

UniGene: Hs.370379

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