YARS2 Antibody

文獻引用 (1) 說明書

中文名稱：

YARS2兔多克隆抗體
貨號：

CSB-PA903762
規(guī)格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA903762(YARS2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)

The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA903762(YARS2 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)

Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-5: NIH/3T3 cells, A172 cells, HepG2 cells, K562 cells, Hela cells, Primary antibody: CSB-PA903762(YARS2 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds
其他：

產(chǎn)品詳情
產(chǎn)品評價
引用文獻
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靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q9Y2Z4
基因名：

YARS2
別名：

CGI 04 antibody; FLJ13995 antibody; mitochondrial antibody; MLASA2 antibody; mt TyrRS antibody; SYYM_HUMAN antibody; Tyrosine tRNA ligase 2 mitochondrial antibody; Tyrosine tRNA ligase antibody; Tyrosine tRNA ligase mitochondrial antibody; Tyrosine--tRNA ligase antibody; Tyrosyl tRNA synthetase 2 mitochondrial antibody; Tyrosyl tRNA synthetase mitochondrial precursor antibody; Tyrosyl-tRNA synthetase antibody; TyrRS antibody; YARS 2 antibody; YARS2 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human,Mouse,Rat
免疫原：

Fusion protein of Human YARS2
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA,WB,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
WB	1:500-1:2000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

引用文獻

Association Analysis of Single-Cell RNA Sequencing and Proteomics Reveals a Vital Role of Ca2+ Signaling in the Determination of Skeletal Muscle Development Potential. K Qiu,Cells,2020

產(chǎn)品評價

靶點詳情

功能：

Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
基因功能參考文獻：
1. The p.Leu392Ser variant is likely a newly identified founder YARS2 mutation in mitochondrial myopathy. PMID: 28395030
2. The mutation in YARS2 gene is a nuclear modifier for the phenotypic manifestation of Leber's hereditary optic neuropathy-associated mitochondrial DNA mutation. PMID: 26647310
3. Data identified novel YARS2 mutations and noted marked phenotypic variability among YARS2 MLASA patients, with phenotypes ranging from mild to lethal, suggesting that the background mtDNA haplotype may be contributing to the phenotypic variability. PMID: 24344687
4. The study confirms mutations in YARS2 as a cause of MLASA and shows that, like some of the cytoplasmic ARSs, mitochondrial ARSs occur in high-molecular-weight complexes. PMID: 22504945
5. first example of a TyrRS lacking specificity toward N1-N72 and thus of a TyrRS disobeying the identity rules PMID: 15840810
6. The YARS2 mutation reported here is an alternative cause of MLASA. PMID: 20598274
7. The gene for mitochondrial tyrosyl-tRNA synthetase is described and the initial characterization of the enzyme is reported. Genes for the remaining missing synthetases have also been found with the exception of human glutaminyl-tRNA synthetase. PMID: 15779907
8. the structure of a strictly mitochondrial human synthetase, namely tyrosyl-tRNA synthetase (mt-TyrRS), in complex with an adenylate analog at 2.2 A resolution PMID: 17997975
9. the apparent occurrence of an unusual TG 3' splice site in intron 5 is discussed PMID: 17672918
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相關(guān)疾病：

Myopathy with lactic acidosis and sideroblastic anemia 2 (MLASA2)
亞細胞定位：

Mitochondrion matrix.
蛋白家族：

Class-I aminoacyl-tRNA synthetase family
數(shù)據(jù)庫鏈接：

HGNC: 24249

OMIM: 610957

KEGG: hsa:51067

STRING: 9606.ENSP00000320658

UniGene: Hs.505231

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