XAF1 Antibody, FITC conjugated

說(shuō)明書(shū)

中文名稱(chēng)：

XAF1兔多克隆抗體, FITC偶聯(lián)
貨號(hào)：

CSB-PA764111LC01HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱(chēng)：

Rabbit anti-Homo sapiens (Human) XAF1 Polyclonal antibody
Uniprot No.：

Q6GPH4
基因名：

XAF1
別名：

BIRC 4 binding protein antibody; BIRC4 binding protein antibody; BIRC4-binding protein antibody; BIRC4BP antibody; HSXIAPAF 1 antibody; HSXIAPAF1 antibody; XAF 1 antibody; XAF1 antibody; XAF1_HUMAN antibody; XIAP associated factor 1 antibody; XIAP-associated factor 1 antibody; XIAPAF1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human XIAP-associated factor 1 protein (172-259AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

FITC
克隆類(lèi)型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondria, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.
基因功能參考文獻(xiàn)：
1. this study uncovers an important role for XAF1-MT2A antagonism as a linchpin to govern cell fate under various stressful conditions including heavy metal exposure. PMID: 28507149
2. XAF1 expression was markedly altered in non-small cell lung cancer tumor samples when compared to that found in normal lung tissues. PMID: 28560416
3. XAF1 expression was associated with VM in ovarian cancer, suggesting a potential role of XAF1 in the formation of VM in EOC. PMID: 28534973
4. XAF1 may be a candidate tumor suppressor in neuroblastoma PMID: 27097110
5. Dysfunction of XAF1 is frequent and is regulated through XAF1 promoter hypermethylation in gastric cancer. Circulating methylated XAF1 DNA was associated with tumor burden and malignant progression, which may be a valuable biomarker for diagnosis of gastric cancer, predicting patients' prognosis and monitoring tumor recurrence after surgery treatment. PMID: 23826230
6. XAF1 promoter hypomethylation is associated with high-grade gliomas. PMID: 28122345
7. human genome-wide gene expression profile assay was used to screen the targets of miR-3131. The overexpressed miR-3131 could lead to a significant decrease of DTHD1 and XAF1 mRNA level. PMID: 28034876
8. XAF1 acts as a feedback regulator of the TNF receptor signaling pathway to suppress NF-kappaB activation PMID: 27768232
9. Taken together, our results suggest that ROS generation might be a predisposing event in berberine-induced mitochondrial apoptosis in EBV-transformed B cells through the upregulation of XAF1 and GADD45alpha expression by MAPK and functional p53. PMID: 27121748
10. Expression of XAF1 and TAp73 was also upregulated in casticin-treated T24 cells. PMID: 27349281
11. Data show that X-linked inhibitor of apoptosis protein (XIAP) mRNA and protein expression increased, whereas XIAP-associated factor 1 (XAF1) mRNA and protein expression decreased with the growth of radiation dose and exposure time. PMID: 27048285
12. the present study was the first to construct an adenovirus which coexpressed XAF1 and TNFalpha in the same open reading frame and expressed them proportionally. As AdXAF1&TNFalpha inhibited HCC cells with enhanced efficiency, it may be applicable for the treatment of HCC. PMID: 27121136
13. SHC1 regulates the alternative splicing of XAF1 in extracellular matrix-detachment induced autophagy to coordinate with the anoikic cell death. PMID: 26643258
14. Our study identified a novel splice variant of XAF1 in cancer cells PMID: 25216542
15. Underexpression of XAF1 confers cisplatin-resistance in ovarian carcinoma. PMID: 25824780
16. Restored XAF1 expression inhibits cell proliferation and induces cell apoptosis in human lung adenocarcinoma cell line A549. Furthermore, XAF1 may activate associated apoptotic signaling pathways in A549 cell line. PMID: 25539606
17. Up-regulation of XAF1 distinctly increased apoptosis in colorectal cancer cells administered cisplatin. PMID: 25367849
18. XAF1 stimulates HIPK2-mediated Ser-46 phosphorylation of p53 and XAF1 also steps up the termination of p53-mediated cell-cycle arrest by activating ZNF313. PMID: 25313037
19. XAF1 as a possible sarcoidosis risk gene PMID: 24663488
20. Transcriptionally active p73 induces translocation of XAF-1 during apoptosis caused by melphalan. XAF-1 directly interacts with Puma and promotes Bax translocation during melphalan-induced apoptosis. PMID: 24249729
21. Promoter methylation of the XAF1 gene plays an important role in the carcinogenesis and progression of papillary thyroid carcinoma. PMID: 22944270
22. Missense polymorphisms in XIAP-associated factor-1 is associated with papillary thyroid cancer. PMID: 23645777
23. the role of XAF1 in promoting apoptosis in vascular endothelial cells after DENV2 infection. PMID: 23207547
24. The search of XIAP binding region within XAF1 revealed a modest affinity XIAP(RING) binding site is located at the C-terminal portion of XAF1.We also mapped the interaction sites for XAF1(RBD) on XIAP(RING) by using NMR. PMID: 22811387
25. XAF1 may be involved in ovarian cancer development and up-regulation of XAF1 may confer sensitivity of ovarian cancer cells to cisplatin-mediated apoptosis. PMID: 22759793
26. XAF1 is frequently methylated in esophageal cancer, and XAF1 expression is regulated by promoter region hypermethylation. PMID: 22719195
27. These findings suggest that a potential novel feedback loop exists between XAF1 and wild-type p53 PMID: 21678496
28. The levels of XAF1 protein and mRNA in cancer tissues were significantly lower than those in cancer adjacent and normal lung tissues. PMID: 22088514
29. 5-AZA treatment can induce the expression of XAF1 mRNA and protein in myeloma. PMID: 19549372
30. 5-azacytidine treatment led to XAF1 promoter CpG islands hypomethylation and showed anti-myeloma activity in a time- and concentration-dependent manner. PMID: 19731821
31. XAF1 down-regulation may contribute to the prostate cancer development PMID: 21143993
32. Demonstrate that p53 could suppress the transcription of XAF1 through interaction with a high affinity responsive element (-95 to -86 nt) within XAF1 promoter in gastrointestinal cancer cells. PMID: 20198350
33. INFalpha and 5-AZA-CdR can induce Xaf1 mRNA expressions in HL-60 and K562 cells. PMID: 18250043
34. The high expression of HSF1 in gastro-intestinal cancer is associated with suppressed expression of XAF1. PMID: 17884799
35. XAF1 is a valuable prognostic marker in pancreatic cancer and could be a potential candidate for cancer gene therapy. PMID: 19922503
36. The expression levels of the pro-apoptotic XAF-1 gene modulate the cytotoxic response to Nutlin-3 in B chronic lymphocytic leukemia. PMID: 19847196
37. XAF1 augments TRAIL-induced apoptosis PMID: 12029096
38. Epigenetic silencing of XAF1 by aberrant promoter methylation may contribute to the malignant progression of human gastric tumors. PMID: 14612497
39. XAF1 expression in melanoma tissues was significantly reduced compared with benign melanocytic nevi PMID: 15610524
40. endogenous stress pressure in cancer cells sustained the high level expression of HSF1 and subsequently suppressed XAF1 expression, implicating the synergized effect of two anti-apoptotic protein families in cytoprotection under stress circumstances PMID: 16303760
41. The ratio of XAF1(A) and XAF1C mRNA expression differs amongst the cell lines tested, suggesting differential mRNA stabilities and/or the existence of tissue- or cell type-specific splicing regulation. PMID: 16343440
42. alternative splicing of XAF1 mRNA leads to formation of truncated XAF1 protein, which likely affects its functional interaction with XIAP, and consequently, contributes to pathogenesis of prostate cancers by disrupting balance of apoptosis machinery PMID: 16353137
43. Gene expression incresed in multiple sclerosis patients treated with interferon-beta. PMID: 16459719
44. siRNA to XAF1 inhibited IFN-induced apoptosis; conversely, overexpression of XAF1 overcame resistance to apoptosis induction by IFN-beta. PMID: 16801630
45. Epigenetic alteration of XAF1 is frequent in human urogenital cancers and may contribute to the malignant progression of tumors by rendering tumor cells a survival advantage partially through the attenuated p53 response. PMID: 16909101
46. Down-regulation of XAF1 in association with hypermethylation was detected in 3 of 4 human gastric cancer cell lines and 6 of 8 colon cancer cell lines. PMID: 17087954
47. In cancerization of oral mucosa, XIAP protein could play an important antiapoptotic role by overexpression, while XAF1 protein does not appear to antagonize effectively the role of XIAP. PMID: 17331366
48. Our study provides evidence that XAF1 is a crucial interferon-stimulated gene (ISG) mediator of IFN-induced sensitization to TRAIL in cancer. PMID: 17376236
49. Low XAF1 mRNA expression levels relate to an unfavorable clinical course in renal cell carcinoma. PMID: 17449173
50. An increased expression ratio of XIAP to XAF1 in combination with a disturbed expression of the XAF1 splice variants could be shown in gastric adenocarcinomas. PMID: 17471152
顯示更多

收起更多
亞細(xì)胞定位：

Cytoplasm. Nucleus. Mitochondrion. Note=Found in the cytoplasm and nucleus of placental syncytiotrophoblasts. Translocates to mitochondria upon TNF-alpha treatment.; [Isoform 1]: Nucleus.; [Isoform 5]: Nucleus.
組織特異性：

Widely expressed. Expression is frequently down-regulated in cancer cell lines. Isoform 5 is widely expressed. Expressed in placenta (at protein level).
數(shù)據(jù)庫(kù)鏈接：

HGNC: 30932

OMIM: 606717

KEGG: hsa:54739

STRING: 9606.ENSP00000354822

UniGene: Hs.441975

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human
WDR5 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human