USP12 Antibody

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) USP12 Polyclonal antibody
Uniprot No.：

O75317
基因名：

USP12
別名：

Deubiquitinating enzyme 12 antibody; OTTHUMP00000042337 antibody; UBH 1 antibody; UBH1 antibody; Ubiquitin carboxyl terminal hydrolase 12 antibody; Ubiquitin carboxyl-terminal hydrolase 12 antibody; Ubiquitin hydrolyzing enzyme 1 antibody; Ubiquitin specific peptidase 12 antibody; Ubiquitin specific processing protease 12 antibody; Ubiquitin specific protease 12 like 1 antibody; Ubiquitin thioesterase 12 antibody; Ubiquitin thiolesterase 12 antibody; Ubiquitin-hydrolyzing enzyme 1 antibody; Ubiquitin-specific-processing protease 12 antibody; UBP12_HUMAN antibody; USP 12 antibody; Usp12 antibody; USP12L1 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 12 protein (1-370AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，USP12 Antibody (CSB-PA025699LA01HU)，的標記方式是Non-conjugated。對于USP12 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA025699LB01HU	USP12 Antibody, HRP conjugated	ELISA
FITC	CSB-PA025699LC01HU	USP12 Antibody, FITC conjugated
Biotin	CSB-PA025699LD01HU	USP12 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:200-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability.
基因功能參考文獻：
1. Usp12 deubiquitylates and prevents lysosomal degradation of LAT and Trat1 to maintain the proximal TCR complex for the duration of signaling. PMID: 26811477
2. Usp12 directly deubiquitinates and stabilises the Akt phosphatases PHLPP and PHLPPL resulting in decreased levels of active pAkt. PMID: 25216524
3. our results reveal WDR48 and USP12 as novel PHLPP1 regulators and potential suppressors of tumor cell survival PMID: 24145035
4. Usp12 acts in a pro-proliferative manner by stabilizing AR and enhancing its cellular function. PMID: 24056413
5. The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation. PMID: 22778262
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蛋白家族：

Peptidase C19 family, USP12/USP46 subfamily
數據庫鏈接：

HGNC: 20485

OMIM: 603091

KEGG: hsa:219333

STRING: 9606.ENSP00000282344

UniGene: Hs.42400

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