UBE2T Antibody

說明書

中文名稱：

UBE2T兔多克隆抗體
貨號：

CSB-PA025480GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9NPD8
基因名：

UBE2T
別名：

Cell proliferation inducing gene 50 protein antibody; Cell proliferation-inducing gene 50 protein antibody; HSPC150 antibody; HSPC150 protein similar to ubiquitin conjugating enzyme antibody; PIG50 antibody; Ube2t antibody; UBE2T_HUMAN antibody; Ubiquitin carrier protein T antibody; Ubiquitin conjugating enzyme antibody; ubiquitin conjugating enzyme E2 T antibody; Ubiquitin conjugating enzyme E2T antibody; Ubiquitin protein ligase T antibody; Ubiquitin-conjugating enzyme E2 T antibody; Ubiquitin-protein ligase T antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human UBE2T
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IF
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in mitomycin-C (MMC)-induced DNA repair. Acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. Also mediates monoubiquitination of FANCL and FANCI. May contribute to ubiquitination and degradation of BRCA1. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination.
基因功能參考文獻：
1. Results show that UBE2T expression was increased in gastric tumors. Its suppression altered the expression of epithelial-mesenchymal transition factors and inhibited growth and colony formation, increased G2/M phase cell cycle arrest, and promoted apoptosis in gastric cancer cells. These findings provide evidence that UBE2T plays a critical role in gastric cancer. PMID: 28427240
2. High UBE2T expression is associated with nasopharyngeal carcinoma. PMID: 26943030
3. Collectively, our findings suggest UBE2T serves as a promising prognostic factor for HCC and functions as an oncogene. The newly identified miR-543/UBE2T/p53 axis may represent a new potential therapeutic target for HCC intervention. PMID: 28935368
4. report the identification of a new allosteric pocket on Ube2T through a fragment screening using biophysical methods. Several fragments binding to this site inhibit ubiquitin conjugation in vitro PMID: 28437106
5. Results showed that UBE2T was overexpressed in osteosarcoma tissues and cell lines. Moreover, UBE2T knockdown inhibited osteosarcoma cell proliferation, migration, and invasion. PMID: 27712593
6. UBE2T plays an important role in the tumorigenesis of gastric cancer and could act as a potential independent prognostic factor for cancer therapy. PMID: 27020591
7. Identify critical roles of UBE2T in prostate cancer development and progression. PMID: 26308072
8. we identified UBE2T as a bona fide FA gene (FANCT) that also may be a rare cancer susceptibility gene. PMID: 26085575
9. UBE2T is the primary E2 of the FA pathway required for FANCD2 and FANCI activation. PMID: 26119737
10. Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia PMID: 26046368
11. hypoxic conditions down-regulate UBE2T expression which correlates with an increased sensitivity to crosslinking agents consistent with a defective Fanconi anemia pathway PMID: 21722982
12. UBE2T is the ubiquitin-conjugating enzyme (E2) in the Fanconi anemia pathway and has a self-inactivation mechanism that could be important for negative regulation of the Fanconi anemia pathway. PMID: 16916645
13. UBE2T was significantly upregulated in lung cancer tissue and cell lines, suggesting involvement of UBE2T in the malignant cell phenotype. PMID: 18667844
14. This work therefore establishes a system that provides mechanistic insight into the functions of FANCL and FANCI in the catalysis of FANCD2 monoubiquitination. PMID: 19111657
15. Upon the occurrence of DNA damage, FANCI becomes monoubiquitinated on Lys-523 by the UBE2T-FANCL pair. PMID: 19589784
16. Our data imply a critical role of UBE2T in development and/or progression of breast cancer through the interaction with and the regulation of the BRCA1/BARD1 complex. PMID: 19887602
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相關疾病：

Fanconi anemia complementation group T (FANCT)
亞細胞定位：

Nucleus. Note=Accumulates to chromatin.
蛋白家族：

Ubiquitin-conjugating enzyme family
數據庫鏈接：

HGNC: 25009

OMIM: 610538

KEGG: hsa:29089

STRING: 9606.ENSP00000356243

UniGene: Hs.5199

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