TRIM59 Antibody, Biotin conjugated

說明書

中文名稱：

TRIM59兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA808999LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TRIM59 Polyclonal antibody
Uniprot No.：

Q8IWR1
基因名：

TRIM59
別名：

TRIM59; RNF104; TRIM57; TSBF1; Tripartite motif-containing protein 59; RING finger protein 104; Tumor suppressor TSBF-1
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Tripartite motif-containing protein 59 protein (126-181AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May serve as a multifunctional regulator for innate immune signaling pathways.
基因功能參考文獻：
1. TRIM59 expression is upregulated in hepatocellular carcinoma (HCC) cells; TRIM59 promotes cell proliferation, migration and invasion in HCC cells PMID: 29442042
2. The level of TRIM59 is correlated with malignant features of colorectal carcinoma (CRC)and may serve as potential therapeutic and preventive strategies for CRC PMID: 28849218
3. Knockdown of TRIM59 may be a promising strategy concerning the early detection and treatment of Renal cell carcinoma. PMID: 28719348
4. TRIM59 overexpression is associated with colorectal cancer metastasis. PMID: 28534983
5. our results suggest that rs1141023 polymorphism contributes to increased predisposition to gastric cancer PMID: 28009992
6. The expression of TRIM59 was significantly elevated in cervical cancers. PMID: 27662486
7. These data suggest the oncogenic abilities of TRIM59 in osteosarcoma, which promote osteosarcoma cell proliferation, migration and invasion PMID: 27121462
8. we knocked down TRIM59 and found that p53 protein expression levels did not upregulate, so we proposed that TRIM59 may promote NSCLC cell growth through other pathways but not the p53 signaling pathway PMID: 26599082
9. TRIM59 interacts with P53, promoting its ubiquitination and degradation, and TRIM59 might promote gastric carcinogenesis via this mechanism. PMID: 25046164
10. These findings indicate that TRIM59 may serve as a multifunctional regulator for innate immune signaling pathways. PMID: 22588174
11. PMID:12095697 pertains to mouse Mrf1 gene which appears to be the homolog of human TSBF1. PMID: 12095697
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亞細胞定位：

Endoplasmic reticulum membrane; Single-pass membrane protein.
蛋白家族：

TRIM/RBCC family
數據庫鏈接：

HGNC: 30834

OMIM: 616148

KEGG: hsa:286827

STRING: 9606.ENSP00000311219

UniGene: Hs.212957

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