TRDMT1 Antibody, FITC conjugated

說明書

中文名稱：

TRDMT1兔多克隆抗體, FITC偶聯
貨號：

CSB-PA675694LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) TRDMT1 Polyclonal antibody
Uniprot No.：

O14717
基因名：

TRDMT1
別名：

dDNMT antibody; DmMT 2 antibody; DmMT2 antibody; DNA (cytosine 5 ) methyltransferase 2 antibody; DNA (cytosine 5) methyltransferase like protein 2 antibody; DNA (cytosine-5)-methyltransferase-like protein 2 antibody; DNA 5 cytosine methyltransferase antibody; DNA methyltransferase 2 antibody; DNA methyltransferase homolog HsaIIP antibody; DNA MTase homolog HsaIIP antibody; Dnmt 2 antibody; Dnmt2 antibody; M.HsaIIP antibody; MHsaIIP antibody; nmt 2 antibody; nmt2 antibody; OTTHUMP00000045198 antibody; PuMet antibody; RNMT 1 antibody; RNMT1 antibody; TRDMT 1 antibody; TRDMT_HUMAN antibody; TRDMT1 antibody; tRNA (cytosine 5 ) methyltransferase antibody; tRNA (cytosine(38)-C(5))-methyltransferase antibody; tRNA aspartic acid methyltransferase 1 antibody; tRNA aspartic acid methyltransferase 1 variant 1 antibody; tRNA aspartic acid methyltransferase 1 variant 2 antibody; tRNA aspartic acid methyltransferase 1 variant 3 antibody; tRNA aspartic acid methyltransferase 1 variant 4 antibody; tRNA aspartic acid methyltransferase 1 variant 5 antibody; tRNA aspartic acid methyltransferase 1 variant 8 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human tRNA (cytosine(38)-C(5))-methyltransferase protein (170-269AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Specifically methylates cytosine 38 in the anticodon loop of tRNA(Asp).
基因功能參考文獻：
1. Data suggest that, upon HIV-1 infection, DNMT2 is re-localized from the nucleus to cytoplasmic stress granules where DNMT2 methylates HIV-1 messenger RNA; this methylation increases the stability of the HIV-1 RNA genome and up-regulates virus replication; thus, DNMT2 appears to facilitate HIV-1 infection. PMID: 28476776
2. The strong effect of some of the somatic cancer mutations on DNMT2 activity suggests that these mutations have a functional role in tumorigenesis. PMID: 25747896
3. Mapped is the tRNA binding site of DNMT2 by systematically mutating surface-exposed lysine and arginine residues to alanine and studying the tRNA methylation activity and binding of the corresponding variants. PMID: 22591353
4. the role of Dnmt2 in stress granules could represent a primitive cellular defense mechanism against viral infection. PMID: 20864816
5. identification of residual DNA-(cytosine-C5) methyltransferase activity PMID: 12794065
6. cDNA microarray analysis identified several genes involved in DNA methylation, such as DNMT2 and DNMT3a that were more highly expressed in LNCaP-r (an androgen sensitive prostate cancer cell line). PMID: 16173030
7. genetic and biochemical approach revealed that DNMT2 did not methylate DNA but instead methylated aspartic acid transfer RNA (tRNA(Asp)) and that DNMT2 specifically methylated cytosine 38 in the anticodon loop PMID: 16424344
8. An association study of 45 folate-related genes in spina bifida: Involvement of tRNA aspartic acid methyltransferase 1 (TRDMT1) PMID: 19161160
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亞細胞定位：

Cytoplasm.
蛋白家族：

Class I-like SAM-binding methyltransferase superfamily, C5-methyltransferase family
組織特異性：

Ubiquitous. Higher expression in testis, ovary and thymus and at much lower levels in spleen, prostate, colon, small intestine, and peripheral blood leukocytes.
數據庫鏈接：

HGNC: 2977

OMIM: 602478

KEGG: hsa:1787

STRING: 9606.ENSP00000367030

UniGene: Hs.351665

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