TMEM9 Antibody

中文名稱：

TMEM9兔多克隆抗體
貨號：

CSB-PA023894LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA023894LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA023894LA01HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品描述：

CUSABIO generates the TMEM9 antibody by immunizing rabbits with the recombinant human TMEM9 (111-183AA). The resulting antibody is a polyclonal antibody and occurs as an unconjugated IgG. It is purified by protein G and reaches up to 95% in purity. And it is only reactive with human TMEM9 protein, which facilitates v-ATPase (vacuolar adenosine triphosphatase) assembly for vesicular acidification and lysosomal protein degradation. Studies have shown that TMEM9 hyperactivates Wnt signaling for liver regeneration and tumorigenesis through lysosomal degradation of APC. This TMEM9 antibody is suitable for the detection of the TMEM9 protein in ELISA and IHC analyses.
產品名稱：

Rabbit anti-Homo sapiens (Human) TMEM9 Polyclonal antibody
Uniprot No.：

Q9P0T7
基因名：

TMEM9
別名：

TMEM9 antibody; DERP4 antibody; TMEM9A antibody; HSPC186 antibody; PSEC0012 antibody; UNQ631/PRO1248 antibody; Transmembrane protein 9 antibody; Dermal papilla-derived protein 4 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Transmembrane protein 9 protein (111-183AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，TMEM9 Antibody (CSB-PA023894LA01HU)，的標記方式是Non-conjugated。對于TMEM9 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA023894LB01HU	TMEM9 Antibody, HRP conjugated	ELISA
FITC	CSB-PA023894LC01HU	TMEM9 Antibody, FITC conjugated
Biotin	CSB-PA023894LD01HU	TMEM9 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking. By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation. TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC. In the liver, involved in hepatic regeneration.
基因功能參考文獻：
1. TMEM9 plays a significant role in TNF-alpha-enhanced cytokines (IL-6 and IL-1beta) secretion in LX-2 cells and that the canonical Wnt/beta-catenin signaling pathway is involved in the induction of these cytokine expressions. PMID: 30119033
2. TMEM9 knockdown by RNA interference resulted in G1 arrest. PMID: 27220462
3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
4. phylogenetically conserved, widely expressed transmembrane protein with a potential, but unknown function in intracellular transport that localizes to lysosomes and late endosomes PMID: 12359240
5. TMEM9B is a key component of inflammatory signaling pathways and suggest that endosomal or lysosomal compartments regulate these pathways PMID: 18541524
顯示更多

收起更多
亞細胞定位：

Lysosome membrane; Single-pass type I membrane protein. Late endosome membrane; Single-pass type I membrane protein. Endosome, multivesicular body membrane; Single-pass type I membrane protein.
蛋白家族：

TMEM9 family
組織特異性：

Highly expressed in adrenal gland, thyroid gland, testis, ovary and prostate. Moderate expression in trachea, spinal cord, stomach, colon, small intestine and spleen. Low expression in bone marrow, lymph node, thymus and peripheral blood lymphocytes. Expr
數據庫鏈接：

HGNC: 18823

OMIM: 616877

KEGG: hsa:252839

STRING: 9606.ENSP00000356298

UniGene: Hs.181444

Most popular with customers

YWHAG Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
YWHAB Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF, FC

Species Reactivity: Human, Mouse, Rat
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
XRCC5 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC, IF

Species Reactivity: Human
XDH Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WT1 Recombinant Monoclonal Antibody

Applications: ELISA, WB, IHC

Species Reactivity: Human
WFDC2 Recombinant Monoclonal Antibody

Applications: ELISA, WB, FC

Species Reactivity: Human
WDR5 Recombinant Monoclonal Antibody

Applications: ELISA, IHC, FC

Species Reactivity: Human