TLE1 Antibody

說(shuō)明書(shū)

中文名稱(chēng)：

TLE1兔多克隆抗體
貨號(hào)：

CSB-PA717264ESR1HU
規(guī)格：

￥440
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱(chēng)：

Rabbit anti-Homo sapiens (Human) TLE1 Polyclonal antibody
Uniprot No.：

Q04724
基因名：

TLE1
別名：

E(Sp1) homolog antibody; Enhancer of split groucho 1 antibody; Enhancer of split groucho like protein 1 antibody; Enhancer of split groucho-like protein 1 antibody; ESG antibody; ESG1 antibody; GRG1 antibody; TLE1 antibody; TLE1_HUMAN antibody; Transducin like enhancer of split 1 (E(sp1) homolog Drosophila) antibody; Transducin like enhancer of split 1 antibody; Transducin like enhancer of split 1 homolog of Drosophila E(sp1) antibody; Transducin like enhancer protein 1 antibody; Transducin-like enhancer protein 1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Transducin-like enhancer protein 1 protein (501-770AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

Non-conjugated
克隆類(lèi)型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA
Protocols：

ELISA Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
基因功能參考文獻(xiàn)：
1. The majority of malignant rhabdoid tumors and atypical teratoid/rhabdoid tumor cases showed some TLE1 immunoreactivity (n = 16; 89% for >/=1 + staining); 14 (78%) of total cases showed >/=2 + positivity using any of the 3 scoring systems. Over half (n = 10; 56%) of cases showed >/=2 + staining; 4 (22%) cases showed 3 + strong and diffuse TLE1 staining measured by all scoring systems in agreement. PMID: 29490565
2. Immunohistochemical analysis for TLE1 can identify basal cell adenomas and basal cell adenocarcinomas by luminal cell staining difference, especially indistinct luminal cell expression for TLE1 in invasive areas of BCAC. PMID: 30053869
3. TLE1 is a potential immunohistochemical marker for glomus tumors PMID: 28632567
4. studies indicate Bit1 is an inhibitor of EMT and metastasis in lung cancer and hence can serve as a molecular target in curbing lung cancer aggressiveness PMID: 27655370
5. Authors present data indicating that TLE1 is rapidly excluded from the nucleus following epidermal growth factor receptor pathway activation, an effect that likely accounts for its inability to mediate effective repression under such conditions. PMID: 28192406
6. TLE1 is not a stand-alone diagnostic immunohistochemical marker for synovial sarcoma PMID: 27568668
7. Data suggest TLE1 is highly expressed in macrophages cultured in vitro, in macrophages of atherosclerotic plaques, and in macrophages of visceral adipose tissue from obese women; expression of TLE1 is up-regulated upon macrophage activation. PMID: 26763127
8. TLE1 has a role in regulating epithelial-to-mesenchymal transition in A549 cells through its repressive effect on E-cadherin PMID: 25446087
9. There was no difference in TLE-1 staining between different subtypes of synovial sarcoma PMID: 24422953
10. GrG1 is involved in pancreatic cell differentiation, establishing a monohormonal beta cell identity. Grg1 is the predominant Groucho expressed in human beta-cells but acts functionally similarly to Grg3. PMID: 24487024
11. TCF/TLE tetramer complex promotes structural transitions of chromatin to mediate repression. PMID: 24596249
12. highly specific biomarker for synovial sarcoma PMID: 23197007
13. signaling and increases the expression of recombinant recognition sequence binding protein at the Jkappa site (RBP-J) and transducin-like enhancer of Split (TLE). PMID: 23775085
14. Although molecular confirmation is the diagnostic gold standard for synovial sarcoma, TLE1, in view of its high sensitivity may be a useful marker within the optimal IHC panel comprising EMA, BCL2, MIC2, CD34 and CK7 PMID: 23287123
15. TLE1 is selectively upregulated in invasive breast tumors relative to noninvasive ductal carcinoma in situ and normal mammary epithelial tissues. PMID: 22952044
16. TLE1, is a necessary transcriptional component of the ER complex, where it facilitates ER-chromatin interactions. PMID: 21536917
17. Epistatic and biological interactions between TLE1 and NOD2 are involved in inflammatory bowel disease pathogenesis. PMID: 21699783
18. TLE1 is a critical factor for the survival of synovial sarcomas PMID: 21319215
19. Studies suggest that TLE1 and TLE3 might also play roles independent of HESX1 by interacting with other transcription factors like PROP1. PMID: 20181723
20. Biologically, loss of TLE-dependent rRNA gene repression coincides with increased global protein synthesis and enhanced cell proliferation PMID: 20160071
21. Hyperphosphorylation induced by cofactor binding plays a positive role in the regulation of Gro/TLE1 anti-neurogenic activity. PMID: 19956621
22. The transcription co-repressor TLE1 interacted with the intracellular region of gpl30 through its Q domain PMID: 12030375
23. 1.6 A crystal structure of a C-terminal fragment of human Groucho/TLE1, comprising part of the Ser/Pro-rich region and a seven-bladed beta propeller WD40 repeat domain, implicated in protein-protein interactions PMID: 12057191
24. Not only PNRC2 but also the corepressor TLE1 functioned as ERRgamma coactivator in a reporter gene analysis. PMID: 14651967
25. beta-catenin displaces Groucho/TLE from Tcf/Lef by binding to a previously unidentified second, low-affinity binding site on lymphoid enhancer factor 1 PMID: 15768032
26. ESG1 expression in human cells is studied. PMID: 16166252
27. TLE is a robust immunohistochemical marker for synovial sarcoma in humans. PMID: 17255769
28. interaction between Sirt1 and TLE1 is important for mediating repression of NF-kappaB activity PMID: 17680780
29. Knockdown of TLE1 or TLE4 levels increased the rate of cell division of the AML1-ETO-expressing Kasumi-1 cell line, whereas forced expression of either TLE1 or TLE4 caused apoptosis and cell death. PMID: 18258796
30. data suggest that TLE1 epigenetic inactivation contributes to the development of hematologic malignancies by disrupting critical differentiation and growth-suppressing pathways PMID: 18519670
31. Inhibition of cortical neuron differentiation by Groucho/TLE1 requires interaction with WRPW, but not Eh1, repressor peptides PMID: 18611861
32. Results demonstrate that transcriptional repression by PRH is dependent on TLE availability and suggest that subnuclear localization of TLE plays an important role in transcriptional repression by PRH. PMID: 18713067
33. TLX1 interacts with TLE1 via an Eh1-like motif. PMID: 19250647
34. TLE1 expression is by no means specific for synovial sarcoma, being present in a number of tumors, which enter its differential diagnosis. PMID: 19363472
35. Findings confirm, in a prospective diagnostic context, that TLE1 is more sensitive and specific for synovial sarcoma than any other currently available immunohistochemical stains. PMID: 19809272
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亞細(xì)胞定位：

Nucleus. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
蛋白家族：

WD repeat Groucho/TLE family
組織特異性：

In all tissues examined, mostly in brain, liver and muscle.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 11837

OMIM: 600189

KEGG: hsa:7088

STRING: 9606.ENSP00000365682

UniGene: Hs.197320

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