TBX22 Antibody

說明書

中文名稱：

TBX22兔多克隆抗體
貨號：

CSB-PA023253GA01HU
規(guī)格：

￥3,900
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

Q9Y458
基因名：

TBX22
別名：

TBX22 antibody; TBOX22 antibody; T-box transcription factor TBX22 antibody; T-box protein 22 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human TBX22
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis.
基因功能參考文獻：
1. Findings indicate the important role of T-box 22 protein (TBX22) in familial cases with X-linked cleft palate. PMID: 29932061
2. we analysed two TBX22 promoter rs7055763 and rs41307258 single-nucleotide polymorphisms (SNPs) in 173 patients with NSCLP and 176 normal controls of south Indian origin using Kbioscience KASPar chemistry PMID: 25918826
3. These results suggest that a loss-of-function mutation in the X-linked TBX22 promoter may cause the cleft palate through disruption of TBX22-ETS-1 pathway. PMID: 25373698
4. TBX22 is the gene underlying Abruzzo-Erickson syndrome. PMID: 22784330
5. 5 putative missense mutations were identified, 3 located in T-box binding domain (R120Q, R126W, and R151L) that affects DNA binding and/or transcriptional repression. 2 novel C-terminal mutations, P389Q and S400Y, did not affect TBX22 activity. PMID: 21248356
6. Craniofacial expression of human and murine TBX22 correlates with the cleft palate and ankyloglossia (CPX) phenotype observed in CPX patients. PMID: 12374769
7. Four novel TBX22 splice site mutations in North American and Brazilian cleft palate families. PMID: 14729838
8. TBX22 is a target for the small ubiquitin-like modifier SUMO-1 and this modification is required for TBX22 repressor activity. PMID: 17846996
9. TBX22 mutations are responsible for a significant proportion of Thai non-syndromic cleft palate cases. PMID: 17868388
10. Analysis of the TBX22 promoter region revealed seven sequence variants, two of which are associated with cleft palate; this effect is stronger in a subgroup stratified for the presence of ankyloglossia. PMID: 19648124
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相關(guān)疾病：

Cleft palate with or without ankyloglossia, X-linked (CPX); Abruzzo-Erickson syndrome (ABERS)
亞細胞定位：

Nucleus.
組織特異性：

Seems to be expressed at a low level.
數(shù)據(jù)庫鏈接：

HGNC: 11600

OMIM: 300307

KEGG: hsa:50945

STRING: 9606.ENSP00000362390

UniGene: Hs.374253

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