RIC3 Antibody
-
中文名稱：RIC3兔多克隆抗體
-
貨號：CSB-PA019707GA01HU
-
規格：￥3,900
-
其他：
產品詳情
-
Uniprot No.：
-
基因名：RIC3
-
別名：AYST720 antibody; FLJ11608 antibody; PRO1385 antibody; Protein RIC-3 antibody; Resistance to inhibitors of cholinesterase 3 homolog antibody; Resistant to inhibitor of cholinesterase 3 antibody; RIC3 acetylcholine receptor chaperone antibody; Ric3 antibody; RIC3_HUMAN antibody
-
宿主：Rabbit
-
反應種屬：Human,Mouse,Rat
-
免疫原：Human RIC3
-
免疫原種屬：Homo sapiens (Human)
-
抗體亞型：IgG
-
純化方式：Antigen Affinity Purified
-
濃度：It differs from different batches. Please contact us to confirm it.
-
保存緩沖液：PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
-
產品提供形式：Liquid
-
應用范圍：ELISA,IHC
-
Protocols：
-
儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
-
貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
-
用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
-
功能：Molecular chaperone which facilitates proper subunit assembly and surface trafficking of alpha-7 (CHRNA7) and alpha-8 (CHRNA8) nicotinic acetylcholine receptors. May also promote functional expression of homomeric serotoninergic 5-HT3 receptors, and of heteromeric acetylcholine receptors alpha-3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4.
-
基因功能參考文獻：
- Two RIC3 gene haplotypes of four variants: A-G-C-G, and C-A-C-A might relate to either protection against or increased susceptibility to PD in the Han Chinese population, respectively. PMID: 28606768
- RIC3 mutations are not a common cause of PD in the French-Canadian and French populations. PMID: 28153381
- RIC3 is a known chaperone of neuronal nicotinic acetylcholine receptor subunit alpha-7 (CHRNA7). PMID: 27055476
- 5-HT3A-ICD is not only required but also sufficient for interaction with RIC-3 PMID: 27045630
- expression of chaperones such as Ric-3 can influence proteins associating with alpha7-nAChRs PMID: 26258666
- RIC-3 differentially regulates assembly and expression of different nicotinic receptor subunits. These results also show that nicotine-mediated upregulation of alpha4beta2 receptors can be dynamically regulated by the presence of the chaperone, RIC-3. PMID: 23586521
- RIC-3 gene rs1528133 variation was not found to be effective over any analyzed obesity related parameter, but associated with higher glycemic load, protein and fat eating behavior and antihypertensive drug use PMID: 23153976
- Xenopus laevis RIC-3 is more effective than either the homomeric human or C. elegans protein in chaperoning the expression of nematode nicotinic receptor ACR-16 in Xenopus oocytes. PMID: 22970690
- RIC-3 exclusively enhances the surface expression of human homomeric 5-hydroxytryptamine type 3A (5-HT3A) receptors despite direct interactions with 5-HT3A, -C, -D, and -E subunits. PMID: 20522555
- the hric3 locus encodes for multiple transcripts, is likely to produce multiple hric3 isoforms, and hric3 is expressed in neurons and muscles, thus enabling its interactions with nicotinic acetylcholine receptors in vivo PMID: 12821669
- ric-3 appears to be necessary for proper folding and/or assembly of alpha7 receptors in HEK293 cells PMID: 15504725
- RIC-3 may play a role in 5-HT(3A) receptor folding, assembly, or transport to the cell surface PMID: 15809299
- hRIC-3 can act as a specific regulator of alpha7 and 5-HT3 expression at different levels by increasing the number of mature receptors and facilitating its transport to the membrane PMID: 15927954
- Mutations in the ric-3 gene affect maturation of nicotinic acetylcholine receptors. PMID: 17192664
- both isoforms of RIC-3 play a role in determining 5-HT3 receptor composition. PMID: 17609200
- Immunohistochemistry demonstrated the presence of RIC-3 in rat brain localized, in general, in places where alpha7 nAChRs were found. PMID: 18179477
- When expressed in a human cell line, human RIC-3 enhances neuronal nicotinic acetylcholine receptor maturation more efficiently than Drosophila melanogaster RIC-3. PMID: 18208544
- this review provides a brief history of RIC-3--REVIEW PMID: 18246096
- we describe the generation and functional and pharmacological characterization of a Chinese hamster ovary (CHO)-K1 cell line co-expressing the human alpha7 nAChR and RIC-3 PMID: 18471073
- The RIC-3e protein is functionally active and enables surface expression of mature alpha7-nAChRs in cell lines not otherwise permissive for the expression of this receptor. PMID: 18691158
顯示更多
收起更多
-
亞細胞定位：[Isoform 1]: Endoplasmic reticulum membrane; Single-pass membrane protein.; [Isoform 2]: Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
-
蛋白家族：Ric-3 family
-
組織特異性：Broadly expressed, with high levels in muscle, brain, heart, pancreas and testis. In the central nervous system, highest levels are detected in the cerebellum and pituitary gland. Over-expressed in brains from patients with bipolar disease or schizophreni
-
數據庫鏈接：
Most popular with customers
-
-
Phospho-YAP1 (S127) Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human
-
-
-
-
-
-
VDAC1 Recombinant Monoclonal Antibody
Applications: ELISA, WB, IHC
Species Reactivity: Human, Mouse, Rat
