RHBDF1 Antibody

中文名稱：

RHBDF1兔多克隆抗體
貨號：

CSB-PA856909LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA856909LA01HU diluted at 1:200 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA856909LA01HU diluted at 1:200 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) RHBDF1 Polyclonal antibody
Uniprot No.：

Q96CC6
基因名：

RHBDF1
別名：

RHBDF1 antibody; C16orf8 antibody; DIST1 antibody; IRHOM1 antibody; Inactive rhomboid protein 1 antibody; iRhom1 antibody; Epidermal growth factor receptor-related protein antibody; Rhomboid 5 homolog 1 antibody; Rhomboid family member 1 antibody; p100hRho antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Complement factor H-related protein 1 protein (132-221AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，RHBDF1 Antibody (CSB-PA856909LA01HU)，的標記方式是Non-conjugated。對于RHBDF1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA856909LB01HU	RHBDF1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA856909LC01HU	RHBDF1 Antibody, FITC conjugated
Biotin	CSB-PA856909LD01HU	RHBDF1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.
基因功能參考文獻：
1. results explain how loss of the amino terminus in iRhom1 and iRhom2 impairs TNF signaling, despite enhancing ADAM17 activity PMID: 26535007
2. The expression of iRhom1 was increased by endoplasmic reticulum (ER) stressors, such as thapsigargin and tunicamycin, leading to the enhancement of proteasome activity, especially in ER-containing microsomes. PMID: 26109405
3. RHBDF1 is a critical component of a molecular switch that regulates HIF1alpha stability in cancer cells in hypoxia. PMID: 24648344
4. RHBDF1 is a seven-transmembrane protein with a long N-terminal cytoplasmic extension that comprises half of the polypeptide sequence, and is found in the endoplasmic reticulum and Golgi, but not on the cell surface PMID: 15965977
5. RHBDF1 has a pivotal role in sustaining growth signals in epithelial cancer cells and thus may serve as a therapeutic target for treating epithelial cancers. PMID: 18524845
6. RHBDF1 is critically involved in a G protein-coupled receptors ligand-stimulated process leading to the activation of latent epidermal growth factor receptor ligands PMID: 18832597
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亞細胞定位：

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
蛋白家族：

Peptidase S54 family
組織特異性：

Highly expressed in cerebellum, cerebrum, heart, skeletal muscle, placenta, pancreatic islet and testis. Detected at lower levels in colon, kidney, small intestine and lung.
數據庫鏈接：

HGNC: 20561

OMIM: 614403

KEGG: hsa:64285

STRING: 9606.ENSP00000262316

UniGene: Hs.744992

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