Phospho-Map2k5 (Ser311/Thr315) Antibody

說明書

中文名稱：

磷酸化-Map2k5 (Ser311/Thr315)兔多克隆抗體
貨號：

CSB-PA115933
規格：

￥2454
圖片：
Western blot analysis of extracts from Rat and Mouse brain tissue using MEK5(phospho-Ser311/ Thr315) Antibody.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Rattus norvegicus (Rat) Map2k5 Polyclonal antibody
Uniprot No.：

Q62862
基因名：

Map2k5
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Peptide sequence around phosphorylation site of Serine 311 and threonine 315 (V-N-S(p)I-A-K-T(p)-Y-V) derived from Rat MEK5.
免疫原種屬：

Rattus norvegicus (Rat)
克隆類型：

Polyclonal
純化方式：

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:1000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.
基因功能參考文獻：
1. Data indicate that NSC23766-mediated Rac inhibition induces cerebellar granule neurons (CGNs) apoptosis through deactivation of prosurvival MAP Kinase Kinase 5 MEK5/ERK5 kinase signaling. PMID: 25666619
2. The p38-mitogen-activated protein kinase activated protein kinase 2 (MK2) pathway is a component of the signaling cascade regulating oligodendrocyte differentiation. PMID: 20607863
3. nuclear localization of MEK5 and ERK5 is different from that of ERK1/2 and MEK1/2 in resting cells, indicating that each MAPK cascade uses distinct mechanisms PMID: 15075238
4. MEK5-ERK5 cascade plays a pivotal role in the biliary dysgenesis of polycystic kidney rats, and also provide insights into the pathogenesis of Caroli's disease. PMID: 15631999
5. MEK5 and big MAP kinase 1 (BMK1) function downstream of MEKK3 in a signaling cascade that induces calcineurin activity through phosphorylation of MCIP1 PMID: 16415348
6. a novel interaction between the PKA pathway and MAPK signaling cascades and suggest that MK5, but not MK2, is implicated in PKA-induced microfilament rearrangement. PMID: 17947239
7. Data show that the ERK5-MEF2C transcription factor pathway contributes to anti-apoptotic effect of cerebral ischemia preconditioning in the hippocampal CA1 region of rats. PMID: 19103177
8. Several binding motifs for heat shock factor are dispersed in the mouse and rat promoter, and temperature shock transiently enhanced the MAP-kinase-activated kinase 5 transcript levels. PMID: 19484198
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亞細胞定位：

[Isoform Beta]: Cytoplasm, cytosol.; [Isoform Alpha-1]: Membrane. Note=The alternatively spliced exon in alpha isoform resemble conserved sequences that mediate interactions with the cytoskeleton, thereby explaining the differential localization.; [Isoform Alpha-2]: Membrane. Note=The alternatively spliced exon in alpha isoform resemble conserved sequences that mediate interactions with the cytoskeleton, thereby explaining the differential localization.
蛋白家族：

Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase subfamily
組織特異性：

MEK5 beta is ubiquitously distributed with highest levels in the liver, whereas MEK5 alpha is expressed only in liver and brain.
數據庫鏈接：

KEGG: rno:29568

STRING: 10116.ENSRNOP00000050528

UniGene: Rn.11054

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