PSD Antibody
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中文名稱：PSD兔多克隆抗體
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貨號：CSB-PA018842LA01HU
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規格：￥440
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圖片：
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Western Blot
Positive WB detected in: MCF-7 whole cell lysate
All lanes: PSD antibody at 3.2µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 110, 71 kDa
Observed band size: 110 kDa -
Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA018842LA01HU at dilution of 1:100 -
Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA018842LA01HU at dilution of 1:100
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) PSD Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：PSD antibody; EFA6 antibody; EFA6A antibody; KIAA2011 antibody; PSD1 antibody; TYL antibody; PH and SEC7 domain-containing protein 1 antibody; Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 antibody; Exchange factor for ARF6 antibody; Exchange factor for ARF6 A antibody; Pleckstrin homology and SEC7 domain-containing protein 1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human PH and SEC7 domain-containing protein 1 protein (247-489AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，PSD Antibody (CSB-PA018842LA01HU)，的標記方式是Non-conjugated。對于PSD Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Guanine nucleotide exchange factor for ARF6. Induces cytoskeletal remodeling.
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基因功能參考文獻：
- Arf GTPases are likely to be locally activated by EFA6 and in turn targeted to the Flemming body to complete cytokinesis. PMID: 26330566
- PSD expression might be a useful biomarker for epigenetic-based gastric cancer early diagnosis and may lead to the identification of new targets for pharmacological intervention. PMID: 25355626
- EFA6 is regulated by a negative feedback loop, which is mediated by an allosteric interaction of Arf6-GTP with a domain of EFA6 and monitors the activation of Arf1 and Arf6 differentially PMID: 25114232
- EFA6 participates in activation of Arf6 around the cleavage furrow during cytokinesis. PMID: 23603394
- Aberrant methylation of PSD occurs in UC-associated colorectal mucosa, enabling circumvention of Rac1 immune responses governing neutrophil chemotaxis and apoptosis, and plays a pivotal role in the mechanisms underlying UC-associated carcinogenesis. PMID: 22179719
- Both levels of accumulation of F-actin and apoptosis were significantly decreased in specimens from UC patients with PSD methylation compared to those without PSD methylation. PMID: 22002136
- Pleckstrin is a critical molecule for proinflammatory cytokine secretion in response to elevated advanced glycation end products (AGE) in diabetes. PMID: 17579087
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亞細胞定位：Cell membrane. Cell projection, ruffle membrane. Cleavage furrow.
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蛋白家族：PSD family
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組織特異性：Isoform 2 is expressed in the brain.
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數據庫鏈接：
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