POLR1C Antibody

中文名稱：

POLR1C兔多克隆抗體
貨號：

CSB-PA018324LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: HEK293 whole cell lysate, K562 whole cell lysate, NIH/3T3 whole cell lysate, HepG2 whole cell lysate, RAW264.7 whole cell lysate, Mouse liver tissue, Mouse kidney tissue, Rat heart tissue
All lanes: POLR1C antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 40, 39 kDa
Observed band size: 40 kDa
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) POLR1C Polyclonal antibody
Uniprot No.：

O15160
基因名：

POLR1C
別名：

40kDa antibody; AA409007 antibody; AA959927 antibody; Ac2-127 antibody; AC40 antibody; AL024089 antibody; DNA directed RNA polymerase I subunit C antibody; DNA directed RNA polymerases I and III 40 kDa polypeptide antibody; DNA directed RNA polymerases I and III subunit RPAC1 antibody; DNA-directed RNA polymerase I subunit C antibody; DNA-directed RNA polymerases I and III 40 kDa polypeptide antibody; DNA-directed RNA polymerases I and III subunit RPAC1 antibody; MGC105583 antibody; MGC161175 antibody; POLR1C antibody; POLR1E antibody; Polymerase (RNA) I polypeptide C, 30kDa antibody; RNA polymerase 1 1 antibody; RNA polymerase I subunit C antibody; RNA polymerases I and III subunit AC1 antibody; RP3-337H4.4 antibody; RPA39 antibody; RPA40 antibody; RPA5 antibody; RPAC1 antibody; RPAC1_HUMAN antibody; RPC40 antibody; Rpo1 1 antibody; TCS3 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse, Rat
免疫原：

Recombinant Human DNA-directed RNA polymerases I and III subunit RPAC1 protein (125-230AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，POLR1C Antibody (CSB-PA018324LA01HU)，的標記方式是Non-conjugated。對于POLR1C Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA018324LB01HU	POLR1C Antibody, HRP conjugated	ELISA
FITC	CSB-PA018324LC01HU	POLR1C Antibody, FITC conjugated
Biotin	CSB-PA018324LD01HU	POLR1C Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:5000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft.
基因功能參考文獻：
1. Treacher Collins syndrome 3-associated mutation leads to the localization of POLR1C into the lysosome and inhibits chondrogenic differentiation, possibly explaining a portion of the pathological molecular basis underlying Treacher Collins syndrome. PMID: 29567474
2. This study is the first to show that distinct mutations in a gene coding for a shared subunit of two RNA polymerases lead to selective modification of the enzymes' availability leading to two different clinical conditions. PMID: 26151409
3. Mutations in TCOF1, POLR1C and POLR1D have all been implicated in causing TCS PMID: 24690222
4. mutations in both alleles of POLR1C in three individuals with Treacher Collins syndrome. PMID: 21131976
5. analyzed the kinetics of assembly and elongation of the RNA polymerase I complex on endogenous ribosomal genes in the nuclei of living cells with the use of in vivo microscopy PMID: 12446911
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相關疾病：

Treacher Collins syndrome 3 (TCS3); Leukodystrophy, hypomyelinating, 11 (HLD11)
亞細胞定位：

Nucleus.
蛋白家族：

Archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family
數據庫鏈接：

HGNC: 20194

OMIM: 248390

KEGG: hsa:9533

STRING: 9606.ENSP00000361465

UniGene: Hs.743509

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