PIP5K1B Antibody

說明書

中文名稱：

PIP5K1B兔多克隆抗體
貨號：

CSB-PA018026ESR1HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA018026ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA018026ESR1HU at dilution of 1:100
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) PIP5K1B Polyclonal antibody
Uniprot No.：

O14986
基因名：

PIP5K1B
別名：

MSS 4 antibody; MSS4 antibody; Phosphatidylinositol 4 phosphate 5 kinase type 1 beta antibody; Phosphatidylinositol-4-phosphate 5-kinase type I beta antibody; Phosphatidylinositol-4-phosphate 5-kinase type-1 beta antibody; PI4P5K 1 beta antibody; PI51B_HUMAN antibody; PIP5K1-beta antibody; PIP5K1B antibody; PIP5KIbeta antibody; Pipk 5 beta antibody; Pipk 5b antibody; Protein STM 7 antibody; Protein STM-7 antibody; PtdIns(4)P-5-kinase 1 beta antibody; STM 7 antibody; STM7 antibody; STM7 LSB antibody; Type I phosphatidylinositol 4 phosphate 5 kinase beta antibody; Type I phosphatidylinositol-4-phosphate 5-kinase beta antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Phosphatidylinositol 4-phosphate 5-kinase type-1 beta protein (190-470AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility. PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion.
基因功能參考文獻：
1. Data indicate that type I phosphatidylinositol 4-phosphate 5-kinase PIP5KIbeta mutants whose dimerization was impaired showed a severe decrease in PI(4,5)P2 production and plasma membrane delocalization. PMID: 25713054
2. Knockdown of PIP5K1B in fibroblasts reproduced abnormal actin cytoskeleton remodeling evidenced in Friedreich's ataxia patient cells. PMID: 23552101
3. Results identify PIPKIbeta as a novel regulator of focal adhesion disassembly and suggest that PIPKIbeta spatially regulates beta1 integrin endocytosis at adhesion sites to control cell migration. PMID: 20624912
4. Results identify an isoform-specific PDZ-binding motif in PIP5KIbeta, which confers specificity for PIP5KIbeta signaling at the uropod during leukocyte chemotaxis. PMID: 20442317
5. findings show that the human type I phosphatidylinositol 4-phosphate 5-kinase isoform beta (PIPKIbeta) has a role in organizing signaling at the cell rear PMID: 18158329
6. Syk-dependent phosphorylation of PIP5K1B is the dominant modification responsible for the decrease in cellular phosphatidylinositol 4,5-bisphosphate. PMID: 19553680
7. Observational study and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 19850283
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亞細胞定位：

Cytoplasm, cytosol. Cell membrane. Endomembrane system.
組織特異性：

Detected in heart, pancreas, brain, kidney, skeletal muscle and lung.
數(shù)據(jù)庫鏈接：

HGNC: 8995

OMIM: 602745

KEGG: hsa:8395

STRING: 9606.ENSP00000265382

UniGene: Hs.534371

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