PCNT Antibody, FITC conjugated

說明書

中文名稱：

PCNT兔多克隆抗體, FITC偶聯(lián)
貨號(hào)：

CSB-PA017627LC11HU
規(guī)格：

￥880
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) PCNT Polyclonal antibody
Uniprot No.：

O95613
基因名：

PCNT
別名：

Centrosome Marker antibody; Ken antibody; Kendrin antibody; KIAA0402 antibody; MOPD2 antibody; PCN antibody; PCNT 2 antibody; PCNT antibody; PCNT B antibody; PCNT_HUMAN antibody; PCNT1 antibody; PCNT2 antibody; PCNTB antibody; PCTN2 antibody; Pericentrin 1 antibody; Pericentrin 2 antibody; Pericentrin 380 antibody; Pericentrin antibody; Pericentrin B antibody; Pericentrin-B antibody; SCKL4 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Pericentrin protein (250-600AA)
免疫原種屬：

Homo sapiens (Human)
標(biāo)記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome.
基因功能參考文獻(xiàn)：
1. High pericentrin expression is associated with Disruptive Cilia Formation in down syndrome. PMID: 30100262
2. we identified two novel mutations in the PCNT gene associated with Microcephalic osteodysplastic primordial dwarfism type II and intracranial aneurysms PMID: 26231886
3. PCNT has to be phosphorylated by PLK1 to be a suitable substrate of separase. PMID: 26647647
4. Cep68 degradation allows Cep215 removal from peripheral pericentriolar material (PCM) preventing centriole separation following disengagement, PCNT cleavage mediates Cep215 removal from core of the PCM to inhibit centriole disengagement and duplication PMID: 25503564
5. The CEP215-pericentrin interaction is required for centrosome maturation and subsequent bipolar spindle formation during mitosis. PMID: 24466316
6. Data suggest that changes in the expression levels of PCNT in DS subjects may be involved into the molecular mechanism of Down's syndrome. PMID: 23979692
7. PCNT gene mutation is associated with hematological abnormalities in patients with microcephalic osteodysplastic primordial dwarfism type II. PMID: 24106199
8. Che-1 depletion abolishes the ability of Chk1 to bind pericentrin and to localize at centrosomes, which, in its turn, deregulates the activation of centrosomal cyclin B-Cdk1 and advances entry into mitosis. PMID: 23798705
9. The pericentrin B cleavage is essential for timely centriole disengagement and duplication. PMID: 22722493
10. Kendrin is a novel and crucial substrate for separase at the centrosome, protecting the engaged centrioles from premature disengagement and thereby blocking reduplication until the cell passes through mitosis. PMID: 22542101
11. Expression of RRP1B, PCNT, KIF21A and ADRB2 in leucocytes of Down's syndrome subjects, was analyzed. PMID: 22552340
12. The pericentrin (PCNT), a PCM protein, was specifically phosphorylated by PLK1 during mitosis. PMID: 22184200
13. PCNT has a crucial role in tooth development; teeth of a patient with a novel homozygous mutation p.Glu1154X are probably the smallest ever reported. PMID: 21567919
14. Severe insulin resistance and premature diabetes are common features of PCNT deficiency but are not congenital. PMID: 21270239
15. Microcephalic osteodysplastic primordial dwarfism type II is a genetically homogeneous condition due to loss-of-function of pericentrin. PMID: 19643772
16. Results found no significant association between the pericentrin gene and schizophrenia in the Japanese population. This gene may not play a major role independently in the etiology of SZ. PMID: 19937158
17. The NESs and NLS of pericentrin are essential for its subcellular localization and nucleocytoplasmic trafficking during the cell cycle.(Pericentrin) PMID: 20567258
18. Data suggest that pericentrin may regulate the intracellular distribution and secretion of insulin. PMID: 20676397
19. CG-NAP and kendrin provide sites for microtubule nucleation in the mammalian centrosome by anchoring gamma-TuRC PMID: 12221128
20. results confirm that MT1-MMP cleaves pericentrin-2 in humans but not in mice and that mouse models of cancer probably cannot be used to critically examine MT1-MMP functionality PMID: 16251193
21. Elevated levels of PCNT2 might be implicated in the pathophysiology of bipolar disorder. PMID: 17884020
22. Mutations in PCNT cause Seckel syndrome with defective ATR-dependent DNA damage signaling. PMID: 18157127
23. study found that biallelic loss-of-function mutations in the centrosomal pericentrin (PCNT) gene on chromosome 21q22.3 cause microcephalic osteodysplastic primordial dwarfism type II (MOPD II) in 25 patients PMID: 18174396
24. Upregulation of pericentrin is associated with increased angiogenesis and prostate tumor cell proliferation PMID: 18701509
25. These findings suggest that the DISC1-kendrin interaction plays a key role in the microtubule dynamics. PMID: 18955030
26. The association of PCNT2 and DBZ with schizophrenia and bipolar disorder in a case-control study of Japanese cohorts, was examined. PMID: 19191256
27. results suggest that genetic variations in the PCNT gene may play a significant role in the etiology of major depressive disorder in the Japanese population PMID: 19448849
28. Results show that a lack of microcephalin or pericentrin results in a loss of Chk1 from centrosomes with subsequently deregulated activation of centrosomal cyclin B-Cdk1. PMID: 19546241
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相關(guān)疾病：

Microcephalic osteodysplastic primordial dwarfism 2 (MOPD2)
亞細(xì)胞定位：

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Centrosomal at all stages of the cell cycle. Remains associated with centrosomes following microtubule depolymerization. Colocalized with DISC1 at the centrosome.
組織特異性：

Expressed in all tissues tested, including placenta, liver, kidney and thymus.
數(shù)據(jù)庫鏈接：

HGNC: 16068

OMIM: 210720

KEGG: hsa:5116

STRING: 9606.ENSP00000352572

UniGene: Hs.474069

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