NOX3 Antibody

說明書

中文名稱：

NOX3兔多克隆抗體
貨號：

CSB-PA015960GA01HU
規格：

￥3,900
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9HBY0
基因名：

NOX3
別名：

NOX3; MOX2; NADPH oxidase 3; Mitogenic oxidase 2; MOX-2; gp91phox homolog 3; GP91-3
宿主：

Rabbit
反應種屬：

Human
免疫原：

Human NOX3-Specific
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. Plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity.
基因功能參考文獻：
1. genetic variants in NOX3 may confer susceptibility to antithyroid drug-induced apoptosis of granulocytes. PMID: 28486791
2. In lung transplants, our study highlights a donor-recipient interaction of NOX3 and NFE2L2 that increases the risk of PGD. PMID: 25439478
3. palmitate-induced ROS generation and that NOX3-derived ROS may drive palmitate-induced hepatic insulin resistance through JNK and p38(MAPK) pathways. PMID: 20647313
4. Down-regulation of NOX3 using siRNA prevented TNF-alpha-induced decrease of cellular glycogen. PMID: 20102709
5. Nox3 is regulated by NOXO1, p47phox, and p67phox PMID: 15181005
6. Nox3 functions together with p22(phox) as an enzyme constitutively producing superoxide PMID: 15824103
7. In conclusion, the results demonstrate that NOX3, a reactive oxygen species generating NADPH oxidase, plays an integral role in insulin-induced p42/44 Mitogen-activated protein kinase signal transmission and VEGF-A production. PMID: 16949073
8. Roles for p22phox at several distinct points in the maturation and assembly of a functionally competent Nox3 in the plasma membrane. PMID: 17140397
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亞細胞定位：

Membrane; Multi-pass membrane protein.
數據庫鏈接：

HGNC: 7890

OMIM: 607105

KEGG: hsa:50508

STRING: 9606.ENSP00000159060

UniGene: Hs.247776

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