NLRC5 Antibody, Biotin conjugated

說明書

中文名稱：

NLRC5兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA771457LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) NLRC5 Polyclonal antibody
Uniprot No.：

Q86WI3
基因名：

NLRC5
別名：

Caterpiller protein 16.1 antibody; CLR16.1 antibody; FLJ21709 antibody; FLJ39711 antibody; NLR family, CARD domain containing 5 antibody; NLR family, CARD-containing 5 antibody; NLR family, caspase recruitment domain-containing 5 antibody; NLRC5 antibody; NLRC5_HUMAN antibody; NOD-like receptor C5 antibody; NOD27 antibody; NOD4 antibody; Nucleotide-binding oligomerization domain protein 27 antibody; Nucleotide-binding oligomerization domain protein 4 antibody; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5 antibody; nucleotide-binding oligomerization domains 27 antibody; OTTHUMP00000164675 antibody; Protein Caterpiller 16.1 antibody; Protein NLRC5 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Protein NLRC5 protein (95-208AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Probable regulator of the NF-kappa-B and type I interferon signaling pathways. May also regulate the type II interferon signaling pathway. Plays a role in homeostatic control of innate immunity and in antiviral defense mechanisms.
基因功能參考文獻：
1. Genetic polymorphisms in NLRC5 may be used as prognostic markers of survival of colorectal cancer patients, as well as for survival in response to 5-FU treatment. PMID: 29762254
2. knockdown of NLRC5 attenuates renal ischemia/reperfusion injury in vitro through the activation of PI3K/Akt signaling pathway. PMID: 29655162
3. NLRC5 may act as a key mediator in renal fibroblast activation and fibrogenesis PMID: 29608899
4. obtained 18 pair-wise interactions within and between the NLRC5 ad PD-L1 genes and 6 more when IFNGR variants were added PMID: 29408916
5. Our study, for the first time, identified the possible involvement of a polymorphism within NLRC5 gene as a possible biomarker for periodontitis condition susceptibility among Italian individuals from genetic isolates. PMID: 28122660
6. NLRC5 interacts with miR-34a.NLRC5 role in HPV16 persistence. PMID: 27423514
7. These results demonstrate that NLRC5 promotes hepatocellular carcinoma progression via the AKT/VEGF-A signaling pathway PMID: 27338800
8. NLRC5 not only positively correlates with the increase of beta-catenin but also coordinates the activation of downstream Wnt/beta-catenin signaling pathway, regulating cell proliferation, migration and invasion in hepatocellular carcinoma. PMID: 26975630
9. silencing NLRC5 reduced extracellular matrix expression in keloid fibroblasts through inhibiting the TGF-beta1/Smad signaling pathway. PMID: 27525969
10. CITA/NLRC5 and CIITA are transcriptional regulators that orchestrate the concerted expression of critical components in the MHC class I and class II pathways, respectively. [review] PMID: 27087581
11. NLRC5 expression was significantly associated with the activation of CD8(+) cytotoxic T cells and patient survival in multiple cancer types. Thus, NLRC5 constitutes a novel prognostic biomarker and potential therapeutic target of cancers. PMID: 27162338
12. NLRC5 regulates TGFB1-induced proliferation and activation of hepatic stellate cells during hepatic fibrosis. PMID: 26592197
13. In a transformed cell line, NLRC5 plays a significant role in IL-6 and IL-1Beta secretion. PMID: 25820389
14. NLRC5 function is shaped by reversible ubiquitination, which modulates the NF-kappaB activation switch PMID: 26620909
15. RSV infection of lung epithelial cells induces expression of RIG-I, NLRC5, and subsequent upregulation of HLA-A, HLA-B and HLA-C. PMID: 25972545
16. a novel role for NLRC5 in RIG-I-mediated antiviral host responses against influenza virus infection, distinguished from the role of NLRC5 in MHC class I gene regulation. PMID: 25404059
17. This study presents a detailed functional study of the domains of NLRC5 revealing that the N-terminal domain of human NLRC5 has intrinsic transcriptional activity. PMID: 25127861
18. Unusual structural features revealed by the solution NMR structure of the NLRC5 caspase recruitment domain. PMID: 24815518
19. A model for full-length human NLRC5 was prepared and, besides the closed conformation of monomeric NLRC5, a heptameric platform was also modeled for the opened conformational NLRC5 monomers. PMID: 24044430
20. rhinovirus ion channel protein 2B triggers NLRP3 and NLRC5 inflammasome activation and IL-1beta secretion in bronchial cells PMID: 23815151
21. Expression of NLRC5 positively correlates with histocompatibility class I expression in human tissues. PMID: 22490867
22. NLRC5 can cooperate with X1 box-binding transcription factor RFX and X2 box-binding transcription factor ATF1 in activation of histocompatibility class I promoter region. PMID: 22490869
23. NLRC5 acts as a key transcriptional regulator of MHC I in lymphocytes and support an essential role for NLRs in directing not only innate but also adaptive immune responses. PMID: 22412192
24. NLRC5-mediated MHC class I gene induction requires an intact nuclear localization signal and nuclear distribution of NLRC5. PMID: 22310711
25. NLRC5 was proposed to function as a positive and as a negative regulator of IFN, NF-kappaB, AP-1 signaling and antiviral immunity. (Review) PMID: 22024701
26. NLRC5 is a critical component of inflammasome-dependent interleukin (IL)-1beta secretion in response to a repertoire of stimuli that also activate NLRP3. PMID: 21191067
27. function for NLRC5 in anti-viral innate immune responses PMID: 20538593
28. NLRC5 is identified and characterized as a key regulator of proinflammatory pathways in immune cells. PMID: 20610642
29. suggest that NLRC5 is a transcriptional regulator, orchestrating the concerted expression of critical components in the MHC class I pathway. PMID: 20639463
30. Study identifies NLRC5 as a negative regulator that blocks two central components of the NF-kappaB and type I interferon signaling pathways and suggest an important role for NLRC5 in homeostatic control of innate immunity. PMID: 20434986
31. NLRC5 may represent a molecular switch of interferon (IFN)-gamma activation sequence and IFN-specific response element signaling pathways contributing to antiviral defense mechanisms. PMID: 20061403
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亞細胞定位：

Cytoplasm.
蛋白家族：

NLRP family
組織特異性：

Expressed in spleen, thymus, lung, brain, tonsil, heart and prostate.
數據庫鏈接：

HGNC: 29933

OMIM: 613537

KEGG: hsa:84166

STRING: 9606.ENSP00000262510

UniGene: Hs.528836

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