MYSM1 Antibody

中文名稱：

MYSM1兔多克隆抗體
貨號：

CSB-PA716576LA01HU
規格：

￥440
圖片：
IHC image of CSB-PA716576LA01HU diluted at 1:500 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MYSM1 Polyclonal antibody
Uniprot No.：

Q5VVJ2
基因名：

MYSM1
別名：

2A-DUB antibody; 2ADUB antibody; Histone H2A deubiquitinase antibody; Histone H2A deubiquitinase MYSM1 antibody; KIAA1915 antibody; Myb like SWIRM and MPN domains 1 antibody; Myb like, SWIRM and MPN domain containing protein antibody; Myb like, SWIRM and MPN domains 1 antibody; Myb-like antibody; Myb-like, SWIRM and MPN domains 1 antibody; MYSM 1 antibody; mysm1 antibody; MYSM1 Myb-like, SWIRM and MPN domains 1 antibody; MYSM1_HUMAN antibody; RP4-592A1.1 antibody; SWIRM and MPN domain-containing protein 1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Histone H2A deubiquitinase MYSM1 protein (170-311AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，MYSM1 Antibody (CSB-PA716576LA01HU)，的標記方式是Non-conjugated。對于MYSM1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA716576LB01HU	MYSM1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA716576LC01HU	MYSM1 Antibody, FITC conjugated
Biotin	CSB-PA716576LD01HU	MYSM1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:500-1:1000

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response. Participates in the normal programming of B-cell responses to antigen after the maturation process. Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity. Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes. Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component. Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains. In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors. Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome.
基因功能參考文獻：
1. Data indicate a pathway MYSM1/miR-150/FLT3 that inhibits proliferation of B1a cells, which may be involved in the pathogenesis of systemic lupus erythematosus (SLE). PMID: 27590507
2. this study shows that MYSM1 deficiency is associated with developmental aberrations, progressive bone marrow failure with myelodysplastic features, and increased susceptibility to genotoxic stress PMID: 28115216
3. data suggested that expression of MYSM1 was associated with the progression of CRC and might be a potential biomarker for clinical prognosis PMID: 28498834
4. An in vivo genetic reversion highlights the crucial role of MYSM1 in human hematopoiesis and lymphocyte differentiation PMID: 26220525
5. the biallelic truncation of MYSM1 likely represents the cause of an inherited bone marrow failure syndrome in two siblings PMID: 24288411
6. The SWIRM structure of human MYb-like, Swirm and Mpn domain-containing protein-1 (MYSM1), is reported. PMID: 17428495
7. The identification of histone H2A deubiquitinase (2A-DUB, or KIAA1915/MYSM1) specific for monoubiquitinated H2A (uH2A) that helps in delineating a strategy for specific regulatory pathways of gene activation, is reported. PMID: 17707232
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亞細胞定位：

Nucleus. Cytoplasm.
蛋白家族：

Peptidase M67A family, MYSM1 subfamily
數據庫鏈接：

HGNC: 29401

OMIM: 612176

KEGG: hsa:114803

STRING: 9606.ENSP00000418734

UniGene: Hs.744921

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