MSRA Antibody, FITC conjugated
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中文名稱：MSRA兔多克隆抗體, FITC偶聯(lián)
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貨號：CSB-PA883456LC01HU
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規(guī)格：￥880
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) MSRA Polyclonal antibody
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Uniprot No.：
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基因名：MSRA
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別名：Cytosolic methionine S sulfoxide reductase antibody; Methionine sulphoxide reductase A antibody; Mitochondrial peptide methionine sulfoxide reductase antibody; MSR A antibody; msrA antibody; MSRA_HUMAN antibody; peptide met (O) reductase antibody; Peptide Met(O) reductase antibody; Peptide methionine (S) S oxide reductase antibody; Peptide-methionine (S)-S-oxide reductase antibody; PMSR antibody; Protein methionine S oxide reductase antibody; Protein-methionine-S-oxide reductase antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Mitochondrial peptide methionine sulfoxide reductase protein (24-235AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：FITC
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
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靶點(diǎn)詳情
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功能：Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
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基因功能參考文獻(xiàn)：
- Data show that miR-193b, by directly targeting focal adhesion kinase (FAK), CRK-like proto-oncogene (CRKL), and methionine sulfoxide reductase A (MSRA), regulates focal adhesion signaling and ROS signaling, which play pivotal roles in liposarcomagenesis and adipogenic differentiation. PMID: 28882999
- this study we have identified, for the first time, compounds structurally related to the natural products fusaricidins that markedly activate recombinant bovine and human MsrA and human MsrB. PMID: 26718410
- The association of MsrA haplotypes with executive functions indicated that MsrA is associated with executive function defects in bipolar I disorder patients. PMID: 26117066
- Silencing the expression of the main Msr elements-MsrA, MsrB1, or MsrB2 exacerbates sensitivity toward oxidative stress. PMID: 23988788
- ARD1 has a crucial role in the cellular response to oxidative stress as a bona fide regulator of MSRA. PMID: 25341044
- The functional MSRA rs10903323 G/A polymorphism is associated with coronary artery disease development. PMID: 23880405
- We hypothesize that the activity of MsrA can be employed as a marker for the isolation of stem and progenitor cell subpopulations for cell therapy applications. PMID: 23415806
- The MSRA rs10903323 G/A variant allele is associated with Rheumatoid Arthritis development, especially among male patients, older patients, C-Reactive Protein-positive patients, and anti-cyclic citrullinated peptide negative patients. PMID: 23244167
- The MSRA rs10903323 gene polymorphism may be implicated in the increased risk to develop cardiovascular events, in particular ischaemic heart disease, observed in rheumatoid arthritis patients. PMID: 22657383
- Mammalian and yeast MSRA reduced free methionine sulfoxide much more efficiently than MSRB. PMID: 22867795
- Data show that glutaredoxin acts as a reductant for methionine sulfoxide reductases A and B (MsrA and MsrB) with or without resolving cysteine. PMID: 22634633
- The haplotype with the lowest P value showed association with Meconium ileus in an independent sample of 1,335 unrelated cystic fibrosis patients PMID: 22438829
- The MSRA gene located on chromosome 8 was found to be associated with the phenotype of schizophrenia in Chinese first-episode schizophrenia patients. PMID: 21679298
- central obesity-associated variants in LYPLAL1, NRXN3, MSRA, and TFAP2B PMID: 21674055
- Data suggest a critical role for TXNL6 in MsrA repair of essential lens proteins under oxidative stress conditions and that TXNL6 is important for MsrA defense protection against cataract. PMID: 21079812
- Our findings indicate that a novel association in the MSRA gene is related to oxidative stress and support the notion of a major role for this process in rheumatoid arthritis. PMID: 20617525
- reduction of MsrA levels results in increased cell proliferation and extracellular matrix degradation, and consequently in a more aggressive cellular phenotype in breast cancer cells PMID: 20937881
- Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20421936
- Dual sites of protein initiation control the localization and myristoylation of methionine sulfoxide reductase A PMID: 20368336
- protein-specific autoantibody are associated with pulmonary fibrosis and renal vascular damage in systemic sclerosis PMID: 19844733
- FOXO3a directly activates the human MsrA promoter in a cell culture system, implying that this could be a conserved mechanism of MsrA regulation. PMID: 19747232
- MSRA is down-regulated during cell aging. PMID: 14759519
- MsrA is present throughout the human lens, where it is likely to defend lens cells and their components against methionine oxidation PMID: 15199188
- The cloning and characterization of the 5' promoter region of human msrA are reported. PMID: 16162094
- MsrA may play an important role in cellular defenses against oxidative stress and in protection against death by limiting the accumulation of oxidative damage to proteins PMID: 16257642
- showed the expression and function of both sulfoxide reductases together with thioredoxin reductase in the cytosol as well as in the nucleus of epidermal melanocytes which are especially sensitive to reactive oxygen PMID: 16480945
- MSRA gene on chromosome 8p might possess metastasis suppressor activity in HCC. PMID: 17784942
- Methionine sulfoxide reductases A and B are seriously affected by hydrogen peroxide accumulation in acute vitiligo. PMID: 17943184
- this work points towards MSRA as a novel schizophrenia candidate gene PMID: 18506707
- Retinoic acid regulates transcription of MSRA gene via two distinct promoters via retinoic acid receptors. PMID: 18845237
- This suggests an important role for an MSRA catalytic antioxidant cycle for protection of the cytoplasmic compartment against oxidative damage. PMID: 19085252
- almost absent catalase and methionine sulfoxide reductase A and B protein expression in human gray/white scalp hair shafts in association with a functional loss of methionine sulfoxide repair in the entire gray hair follicle PMID: 19237503
- MSR enzymes are differentially expressed in human skin PMID: 19542914
- TFAP2B, LYPLAL1 and MSRA are associated with adiposity and fat distribution. PMID: 19557161
- Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 19557161
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亞細(xì)胞定位：[Isoform 1]: Mitochondrion.; [Isoform 2]: Cytoplasm.; [Isoform 3]: Cytoplasm. Nucleus.; [Isoform 5]: Cytoplasm. Membrane; Lipid-anchor.
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蛋白家族：MsrA Met sulfoxide reductase family
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組織特異性：Ubiquitous. Highest expression in adult kidney and cerebellum, followed by liver, heart ventricles, bone marrow and hippocampus.
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