MMP24 Antibody

說明書

中文名稱：

MMP24兔多克隆抗體
貨號：

CSB-PA166201
規格：

￥1100
圖片：
The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using CSB-PA166201(MMP24 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

Uniprot No.：

Q9Y5R2
基因名：

MMP24
別名：

Matrix metallopeptidase 24 (membrane inserted) antibody; Matrix metallopeptidase 24 antibody; Membrane type 5 matrix metalloproteinase antibody; Membrane type matrix metalloproteinase 5 antibody; Membrane-type matrix metalloproteinase 5 antibody; Membrane-type-5 matrix metalloproteinase antibody; MMP 24 antibody; MMP 25 antibody; MMP-24 antibody; Mmp24 antibody; MMP24_HUMAN antibody; MMP25 antibody; MT MMP5 antibody; MT-MMP 5 antibody; MT5 MMP antibody; MT5-MMP antibody; MT5MMP antibody; MTMMP5 antibody; Processed matrix metalloproteinase-24 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthetic peptide of Human MMP24
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
抗體亞型：

IgG
純化方式：

Antigen affinity purification
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
產品提供形式：

Liquid
應用范圍：

ELISA,IHC

推薦稀釋比：

Application	Recommended Dilution
ELISA	1:2000-1:5000
IHC	1:25-1:100

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin.
基因功能參考文獻：
1. MMP24 overexpression is associated with lung cancer metastasis. PMID: 27869830
2. Polymorphisms in MAP3K3, MMP24 and IGF1R are associated with greater height and act additively on height in children of an admixed population. PMID: 26304632
3. In absolute mRNA levels, significant differences were found in expression of MMP2, MMP24, and MMP25 in gastric carcinoma compared with superficial gastritis. PMID: 24669030
4. MMP-24 gene silencing by RNAi can suppress the invasiveness of ovarian cancer SKOV(3) cells in vitro. PMID: 19403421
5. down-regulation of most MT-MMPs is typical for prostate carcinoma; seems to occur mainly in epithelial cells PMID: 12661033
6. MT5-MMP retrieval to the plasma membrane is regulated by Mint-3 by binding to its carboxyl end motif EWV PMID: 14990567
7. MT5-MMP is expressed in normal human endometrium and there is enhanced exprestion in endometrium from patients with entometriosis with strongest signal in epithelial cells. PMID: 17952761
8. These results suggest more than one human MT5-MMP transcript may exist in the central nervous system. PMID: 18062926
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亞細胞定位：

[Matrix metalloproteinase-24]: Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein.; [Processed matrix metalloproteinase-24]: Secreted, extracellular space, extracellular matrix.
蛋白家族：

Peptidase M10A family
組織特異性：

Predominantly expressed in brain, kidney, pancreas and lung. Overexpressed in a series of brain tumors, including astrocytomas and glioblastomas.
數據庫鏈接：

HGNC: 7172

OMIM: 604871

KEGG: hsa:10893

STRING: 9606.ENSP00000246186

UniGene: Hs.715494

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