MED28 Antibody, Biotin conjugated

說明書

中文名稱：

MED28兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA863955LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MED28 Polyclonal antibody
Uniprot No.：

Q9H204
基因名：

MED28
別名：

EG1 antibody; Endothelial-derived protein 1 antibody; FKSG20 antibody; Magicin antibody; med28 antibody; MED28_HUMAN antibody; Mediator complex subunit 28 antibody; Mediator of RNA polymerase II transcription subunit 28 antibody; Merlin and Grb2-interacting cytoskeletal protein antibody; Tumor angiogenesis marker EG-1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Mediator of RNA polymerase II transcription subunit 28 protein (1-178AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways.
基因功能參考文獻：
1. MED28 modulates the development of epithelial-mesenchymal transition through NFkappaB in human breast cancer cells. PMID: 27662245
2. All trans-retinoic acid can reverse the suppressive effect of MED28 on HBP1 and E-cadherin and inactivate the Wnt/beta-catenin pathway in colorectal cancer, suggesting a protective effect of ATRA against colorectal cancer. PMID: 26660958
3. This paper describes a link between Med23 and IFN-lambda3, provides evidence for the crucial role of IFN-lambda in HSV-1 immune control. PMID: 23950709
4. These data indicate that MED28 regulates cellular migration in a MEK1-dependent manner in human breast cancer cells, reinforcing the important cellular roles of MED28. PMID: 22495818
5. High MED28 is associated with breast cancer. PMID: 20584319
6. demonstrate an interaction between Grb2 and magicin. In addition, merlin is capable of forming a ternary complex with magicin and Grb2 PMID: 15467741
7. EG-1 is a positive stimulator of cellular proliferation, and may possibly be involved in signaling pathways involving Src and MAPK activation. PMID: 16024617
8. May serve as a multi-faceted adaptor/scaffold to relay cellular signaling to the cytoskeleton and from the cytoskeleton to the nucleus. PMID: 16899217
9. EG-1 may be involved in signaling pathways including c-Src activation. PMID: 16964398
10. EG-1 has a role in breast tumor growth PMID: 17568184
11. Study reports that down-regulation of human Med28 expression in NIH3T3 cells results in a significant induction of several genes associated with smooth muscle cell (SMC)differentiation; conversely, overexpression of MED28 represses SMC gene expression. PMID: 17848560
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亞細胞定位：

Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Note=According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated.
蛋白家族：

Mediator complex subunit 28 family
組織特異性：

Widely expressed. Highly expressed in vascular tissues such as placenta, testis and liver.
數據庫鏈接：

HGNC: 24628

OMIM: 610311

KEGG: hsa:80306

STRING: 9606.ENSP00000237380

UniGene: Hs.731966

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