MCTS1 Antibody

說(shuō)明書(shū)

中文名稱：

MCTS1兔多克隆抗體
貨號(hào)：

CSB-PA892143HA01HU
規(guī)格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA892143HA01HU at dilution of 1:100

Immunofluorescence staining of PC-3 cells with CSB-PA892143HA01HU at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
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靶點(diǎn)詳情

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) MCTS1 Polyclonal antibody
Uniprot No.：

Q9ULC4
基因名：

MCTS1
別名：

FLJ39637 antibody; Malignant T cell amplified sequence 1 antibody; Malignant T cell-amplified sequence 1 antibody; MCT 1 antibody; MCT-1 antibody; MCT1 antibody; MCTS 1 antibody; MCTS1 antibody; MCTS1_HUMAN antibody; Multiple copies T cell malignancies 1 antibody; Multiple copies T cell malignancies antibody; Multiple copies T-cell malignancies antibody; Oncogene MCT 1 antibody; Oncogene MCT1 antibody
宿主：

Rabbit
反應(yīng)種屬：

Human
免疫原：

Recombinant Human Malignant T-cell-amplified sequence 1 protein (1-181AA)
免疫原種屬：

Homo sapiens (Human)

標(biāo)記方式：

Non-conjugated

本頁(yè)面中的產(chǎn)品，MCTS1 Antibody (CSB-PA892143HA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于MCTS1 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

標(biāo)記方式	貨號(hào)	產(chǎn)品名稱	應(yīng)用
HRP	CSB-PA892143HB01HU	MCTS1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA892143HC01HU	MCTS1 Antibody, FITC conjugated
Biotin	CSB-PA892143HD01HU	MCTS1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產(chǎn)品提供形式：

Liquid
應(yīng)用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:200-1:500

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲(chǔ)存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constitutively expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiple chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.
基因功能參考文獻(xiàn)：
1. PKC inhibitor sotrastaurin induced cell apoptosis and cell cycle arrest in DLBCL cells potentially through regulating the expression of MCT-1 PMID: 29534146
2. findings elucidate how the DENR-MCT-1 dimer interacts with the ribosome and have functional implications for the mechanism of unconventional translation initiation and reinitiation. PMID: 28723557
3. DENR binds to the P-site of the 40S ribosomal subunit and together with MCTS1 forms a tRNA binding surface and interferes with eIF1/eIF2/eIF3 binding, thus operating in post-termination ribosome recycling and translation re-initiation PMID: 28723557
4. Reinitiation complexes involving initiation factors eIF2D, MCT-1, and DENR controls the translation of a large fraction of mammalian cellular mRNAs. PMID: 28732596
5. Overexpression of MCT1 is associated with gliomas. PMID: 23258846
6. MCT-1 is a new centrosomal-associated oncoprotein, and that it plays a novel role in the regulation of mitosis signifies its important function in the process of tumorigenesis. PMID: 22336915
7. The present study indicates possible involvement of a protein kinase (PK)C- and PKA-mediated pathway associated with expression of MCT1 and lactate transport in rhabdomyosarcoma cells. PMID: 20823576
8. The oppositions between MCT-1 and p53 are firstly confirmed at multistage processes that include transcription control, mRNA metabolism, and protein expression PMID: 21138557
9. The result suggest that co-expression of CD147 and MCT1/MCT4 is related to drug resistance during EOC metastasis and could be useful therapeutic targets to prevent the development of incurable, recurrent and drug resistance EOC. PMID: 20658178
10. Results describe the expression and purification of MCT-1 in insect cells using a baculovirus expression system. PMID: 20076993
11. tumor cell lines overexpressing MCT-1 exhibited increased growth rates and displayed increased protection against apoptosis induced by serum starvation PMID: 12637315
12. demonstrated the presence of sequence-specific DNA-binding protein in nuclear extracts designated as LMBF; the 26-mer oligonucleotide containing the LMBF binding site is required for maximum transcriptional activity of the MCT-1 promoter PMID: 12938157
13. role of the MCT-1 in lymphomagenesis PMID: 18824261
14. Loss of p53 and MCT-1 overexpression synergistically promote chromosome instability and tumorigenicity. PMID: 19372582
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亞細(xì)胞定位：

Cytoplasm. Note=Nuclear relocalization after DNA damage.
蛋白家族：

MCTS1 family
組織特異性：

Ubiquitous. Over-expressed in T-cell lymphoid cell lines and in non-Hodgkin lymphoma cell lines as well as in a subset of primary large B-cell lymphomas.
數(shù)據(jù)庫(kù)鏈接：

HGNC: 23357

OMIM: 300587

KEGG: hsa:28985

STRING: 9606.ENSP00000360365

UniGene: Hs.102696

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