MC5R Antibody, HRP conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) MC5R Polyclonal antibody
Uniprot No.：

P33032
基因名：

MC5R
別名：

MC5R; Melanocortin receptor 5; MC5-R; MC-2
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Melanocortin receptor 5 protein (1-37AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.
基因功能參考文獻：
1. Mutations in residues S4/S5 and S17/E18 retained MC5R at the ER/Golgi complex and did not affect MC5R homodimerization. PMID: 28396017
2. D115 and D119 in TM3, F195 in TM5, and F254 in TM6 may form a binding pocket for NDP-alpha-MSH binding. PMID: 23414113
3. Melanocortin 5 receptor signaling and internalization: role of MAPK/ERK pathway and beta-arrestins 1/2. PMID: 22871966
4. Variations in the melanocortin 5 receptor gene are unlikely to confer susceptibility to bipolar disorder in this sample. PMID: 16314755
5. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119 were made at MC5R. PMID: 17482720
6. MC5R signals through a PI3K-regulated Akt-independent pathway leading to downstream activation of ERK1/2 PMID: 19428994
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
組織特異性：

Expressed in the brain but not in the melanoma cells.
數據庫鏈接：

HGNC: 6933

OMIM: 600042

KEGG: hsa:4161

STRING: 9606.ENSP00000318077

UniGene: Hs.248145

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