JPH1 Antibody, Biotin conjugated

說明書

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) JPH1 Polyclonal antibody
Uniprot No.：

Q9HDC5
基因名：

JPH1
別名：

DKFZp762L0313 antibody; JP 1 antibody; JP-1 antibody; JP1 antibody; JPH 1 antibody; JPH1 antibody; JPH1_HUMAN antibody; Junctophilin 1 antibody; Junctophilin type 1 antibody; Junctophilin type1 antibody; Junctophilin-1 antibody; Junctophilin1 antibody; Mitsugumin 72 antibody; Mitsugumin72 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Junctophilin-1 protein (431-546AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
基因功能參考文獻：
1. This study suggests that genetic variants of JPH1 may modulate the effect of smoking on carotid plaque burden. PMID: 24954085
2. This study demonstrates that both JP1 and JP2 in skeletal muscle undergo Ca2+-dependent proteolysis by endogenous proteases when the intracellular Ca2+ is raised within the physiological range for a sustained period PMID: 23148318
3. JP1 and JP2 can facilitate the assembly of DHPR with other proteins of the excitation-contraction coupling machinery PMID: 22020936
亞細胞定位：

Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Sarcoplasmic reticulum membrane; Single-pass type IV membrane protein.
蛋白家族：

Junctophilin family
組織特異性：

Abundantly expressed in skeletal muscle. Very low levels in heart.
數據庫鏈接：

HGNC: 14201

OMIM: 605266

KEGG: hsa:56704

STRING: 9606.ENSP00000344488

UniGene: Hs.657367

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