ITPR3 Antibody
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中文名稱：ITPR3兔多克隆抗體
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貨號：CSB-PA852295
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規格：￥1100
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圖片：
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The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA852295(ITPR3 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200) -
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA852295(ITPR3 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
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其他：
產品詳情
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Uniprot No.：
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基因名：
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別名：4 antibody; 5-trisphosphate receptor antibody; 5-trisphosphate receptor type 3 antibody; FLJ36205 antibody; Inositol 1 antibody; Inositol 1,4,5 trisphosphate receptor type 3 antibody; InsP3R3 antibody; IP3 receptor antibody; IP3 receptor isoform 3 antibody; IP3R 3 antibody; IP3R antibody; IP3R3 antibody; ITPR 3 antibody; ITPR3 antibody; ITPR3_HUMAN antibody; Type 3 inositol 1 antibody; Type 3 inositol 1,4,5 trisphosphate receptor antibody; Type 3 InsP3 receptor antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Synthetic peptide of Human ITPR3
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產品提供形式：Liquid
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應用范圍：ELISA,IHC
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推薦稀釋比：
Application Recommended Dilution ELISA 1:2000-1:10000 IHC 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.
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基因功能參考文獻：
- Data demonstrated that IP3R3 is able to modulate intracellular Ca(2+) availability and to coordinate the remodeling of profilin cytoskeleton organization through the ARHGAP18/RhoA/mDia1/FAK pathway. PMID: 29630900
- Suggest that AT haplotype in the ITPR3 gene may serve as a potential marker for genetic susceptibility to cervical squamous cell carcinoma risk in Taiwanese women. PMID: 28036301
- PTEN counteracts FBXL2 to promote IP3R3- and Ca(2+)-mediated apoptosis limiting tumour growth PMID: 28614300
- BAP1 regulates IP3R3-mediated Ca(2+) flux to mitochondria suppressing cell transformation PMID: 28614305
- The transcription factor NRF2 binds to the promoter of ITPR3 to inhibit its expression in cholangiocytes, leading to reduced calcium signaling and bile duct secretion. PMID: 25796361
- miR-506 is a regulator of InsP3R3 expression and InsP3R3-mediated Ca2+ signaling and secretion. PMID: 25378392
- It mediate calcium release from intracellular calcium stores such as the ER into the cytoplasm. (review) PMID: 24285081
- Physiologically relevant reactive oxygen species controls cytoplasmic and mitochondrial calcium transport through IP3 receptors. PMID: 24469450
- A molecular and functional link between BKCa channel and IP3R3 in cancer cells as an important mechanism for tumor cell proliferation. PMID: 23992640
- in human pulmonary fibroblasts, PDGF acts through IP3-induced Ca(2+)-release to trigger Ca(2+) waves, which in turn modulate gene expression of several matrix proteins. PMID: 23618877
- The presence of isoform III of inositol 1,4,5-trisphosphate receptor is the key point of Akt activity on calcium-mediated apoptosis. PMID: 22552281
- Ins(1,4,5)P3R-mediated Ca2+ signaling was critical for starvation-induced autophagy stimulation. PMID: 22082873
- The study provides biochemical evidence of the interaction between FKBP12 and RYR1, RYR3 and IP3R. PMID: 22100703
- the critical region of KRAP protein for the regulation of IP(3)R was determined. PMID: 21501587
- results of this study suggest that the rs2229634 SNP in the ITPR3 gene is associated with the risk of coronary artery aneurysm formation in Taiwanese Kawasaki disease patients PMID: 20618519
- inositol 145-triphosphate receptor type 3 becomes expressed in colon cancer, and its expression level is directly related to aggressiveness of the tumor PMID: 21075448
- Findings suggest IP(3)R3 as a novel therapeutic target and identify caffeine as a possible adjunct therapy to slow invasive growth of glioblastoma. PMID: 20103623
- IP3R3 may be a prerequisite for secretion of an enzyme, such as protease, in gastric cancer cells; results indicate that IP3R3 may be specifically involved in gastric cancer peritoneal dissemination PMID: 14666665
- The estimated population-attributable risk of 21.6% suggests that variation within ITPR3 reflects an important contribution to type 1 diabetes in Sweden. PMID: 16960798
- Anti-IP(3)R1 antibodies were present in 48.6% of primary Sjogren's syndrome and in 3.0% of normal healthy subjects. PMID: 17437169
- IP3R3 is present in the paranodal regions of the nodes in the sciatic nerve. PMID: 17496801
- A functional single nucleotide polymorphism in the NKX2.5-binding site of ITPR3 promoter is associated with susceptibility to systemic lupus erythematosus PMID: 18219441
- the ankyrin-binding site is located on the cytoplasmic face of the InsP(3) receptor, thus validating the feasibility of in vivo ankyrin-InsP(3) receptor interactions. PMID: 18275062
- The association between type 1 diabetes and the ITPR3 gene polymorphism due to linkage disequilibrium with HLA class II. PMID: 18340361
- In this review, by sensing sequential binding of IP3 and calcium ions, the IP3 receptor acts as a coincidence detector that associates parallel fiber inputs with climbing fiber inputs. PMID: 18434505
- sigma-1R overexpression drives sigma agonist-independent dissociation of ANK 220 from IP3R-3, resulting in activation PMID: 18539593
- the agonist-induced clustering of IP(3)R is triggered by IP(3) binding, rather than [Ca(2+)](i) elevation. PMID: 18544901
- May play a role in calcium-dependent nuclear processes. PMID: 18586264
- IP3-mediated sensitization requires IP3 receptor binding to a TRPV4 C-terminal domain that overlaps with a previously described calmodulin-binding site PMID: 18826956
- Inability of the T-cell receptors in TCR transgenic mice to trigger calcium mobilization may be due to the insufficient level of inositol 1,4,5-triphosphate receptor (IP3) type 3 to initiate the release of calcium from intracellular stores. PMID: 19050248
- Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells. PMID: 19052258
- Results demonstrate the importance of the InsP3 receptor-mutant huntingtin protein association for the pathogenesis of Huntington's disease and as a potential therapeutic target for Huntington's disease. PMID: 19193873
- Data show that the BH4 domain mediates interaction of Bcl-2 with the inositol 1,4,5-trisphosphate (IP3) receptor on the endoplasmic reticulum. PMID: 19706527
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亞細胞定位：Endoplasmic reticulum membrane; Multi-pass membrane protein.
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蛋白家族：InsP3 receptor family
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組織特異性：Expressed in intestinal crypt and villus epithelial cells.
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數據庫鏈接：
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