IFT57 Antibody
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中文名稱：IFT57兔多克隆抗體
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貨號：CSB-PA865156ESR2HU
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規(guī)格：￥440
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圖片：
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Western blot
All lanes: IFT57 antibody at 2μg/ml + Mouse lung tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 49 kDa
Observed band size: 49 kDa -
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA865156ESR2HU at dilution of 1:100
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) IFT57 Polyclonal antibody
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Uniprot No.：
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基因名：IFT57
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別名：CDNA FLJ10147 fis clone HEMBA1003369 antibody; Dermal papilla derived protein 8 antibody; Dermal papilla-derived protein 8 antibody; DERP 8 antibody; DERP8 antibody; Esrrbl 1 antibody; Esrrbl1 antibody; ESRRBL1 protein antibody; Estrogen related receptor beta like 1 antibody; Estrogen related receptor beta like protein 1 antibody; Estrogen-related receptor beta-like protein 1 antibody; FLJ10147 antibody; Hip1 Interacting protein antibody; HIP1 interacting protein HIPPI antibody; Hip1 protein interactor antibody; HIP1-interacting protein antibody; HIPPI antibody; Huntingtin interacting protein 1 interacting protein antibody; Huntingtin interacting protein 1 protein interactor antibody; IFT 57 antibody; ift57 antibody; IFT57_HUMAN antibody; Intraflagellar transport 57 homolog (Chlamydomonas) antibody; Intraflagellar transport 57 homolog antibody; Intraflagellar transport protein 57 homolog antibody; MHS4R2 antibody; Vestrogen related receptor beta like 1 antibody
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宿主：Rabbit
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反應種屬：Human, Mouse
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免疫原：Recombinant Human Intraflagellar transport protein 57 homolog protein (170-429AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產(chǎn)品提供形式：Liquid
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應用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 IHC 1:20-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關產(chǎn)品
靶點詳情
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功能：Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
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基因功能參考文獻：
- sequencing of IFT57 in 13 OFDS subjects and 12 subjects with Ellis-Van Creveld syndrome was negative. This report identifies the implication of IFT57 in human pathology and highlights the first description of a ciliary transport defect in OFDS, extending the genetic heterogeneity of this subgroup of ciliopathies. PMID: 27060890
- HIPPI-P53 interaction was necessary for HIPPI mediated up-regulation of Caspase1 gene. PMID: 21943362
- novel transcription regulatory mechanism of REST by HIPPI may contribute to the deregulation of transcription observed in the cell model of Huntington disease. PMID: 21832040
- Results show that pro-apoptotic Hippi-Hip-1 heterodimers can recruit procaspase-8 into a complex of Hippi, Hip-1 and procaspase-8, and launch apoptosis through components of the 'extrinsic' cell-death pathway. PMID: 11788820
- critical for the death-promoting effects of mutant huntingtin protein in cultured cells PMID: 11807533
- Hippi interacts with the viral death protein Apoptin. PMID: 12745083
- Hippi expression induced apoptosis by releasing AIF and cytochrome c from mitochondria, activation of caspase-1 and caspase-3, and altering the expression of apoptotic genes and genes involved in mitochondrial complex I and II. PMID: 16364650
- Crystals of the pDED of HIPPI were grown in space group P4(1), with unit-cell parameters a = b = 77.42, c = 33.31 A and a calculated Matthews coefficient of 1.88 A3 Da(-1) (33% solvent content) with two molecules per asymmetric unit. PMID: 17142908
- In summary, we showed that HIPPI could interact with the putative promoter sequence of caspase-1 and increased the expression of the downstream gene suggesting that HIPPI could act as transcription regulator. PMID: 17173859
- Over-expression of BLOC1S2 in presence or absence of HIPPI does not induce apoptosis. However, BLOC1S2 & HIPPI sensitize NCH89 glioblastoma cells to pro-apoptotic actions of staurosporine & death ligand TRAIL. PMID: 18188704
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亞細胞定位：Cytoplasm, cytoskeleton, cilium basal body.
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蛋白家族：IFT57 family
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組織特異性：Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level).
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數(shù)據(jù)庫鏈接：
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