HSPB7 Antibody

中文名稱：

HSPB7兔多克隆抗體
貨號：

CSB-PA10979A0Rb
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA10979A0Rb at dilution of 1:100
其他：

產品詳情
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靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) HSPB7 Polyclonal antibody
Uniprot No.：

Q9UBY9
基因名：

HSPB7
別名：

Cardiovascular heat shock protein antibody; cvHsp antibody; DKFZp779D0968 antibody; FLJ32733 antibody; Heat shock 27kda protein family member 7 antibody; Heat shock protein beta 7 antibody; Heat shock protein beta-7 antibody; Hsp25 2 antibody; HspB7 antibody; HSPB7_HUMAN antibody; Hypothetical protein flj34956 antibody; RP11-5P18.6 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Heat shock protein beta-7 protein (1-170AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，HSPB7 Antibody (CSB-PA10979A0Rb)，的標記方式是Non-conjugated。對于HSPB7 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA10979B0Rb	HSPB7 Antibody, HRP conjugated	ELISA
FITC	CSB-PA10979C0Rb	HSPB7 Antibody, FITC conjugated
Biotin	CSB-PA10979D0Rb	HSPB7 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

基因功能參考文獻：
1. Loss of Hspb7 in zebrafish or human cardiomyocytes stimulated autophagic pathways and expression of the sister gene encoding Hspb5. Inhibiting autophagy caused FilaminC aggregation in HSPB7 mutant human cardiomyocytes and developmental cardiomyopathy in hspb7 mutant zebrafish embryos. PMID: 29331499
2. our findings characterize HSPB7 as an intercalated disc protein and suggest it has an essential role in maintaining intercalated disc integrity and conduction function in the adult heart. PMID: 28827800
3. Patients with central sleep apnea and congestive heart failure had higher T allele frequencies in the HSPB7 gene. PMID: 27441470
4. HSPB7 loci is associated in the pathophysiologuy of ischemic heart failure. PMID: 25889438
5. Results imply that HSBP7 is likely to be a tumor suppressor gene regulated by p53 and its downregulation by hypermethylation may play a critical role in renal carcinogenesis. PMID: 24585183
6. HSPB7 is a potential early biomarker after MI and serves as an independent risk factor of ACS in patients with acute chest pain. PMID: 22785082
7. Data show a significant association between a SNP in HSPB7 gene (rs1739843, minor allele frequency 39%) and idiopathic DCM. PMID: 20975947
8. The rs1738943 shows that although this SNP is located within HSPB7, it resides in a block of high LD that spans HSPB7 and a nearby gene, CLCNKA, which encodes a voltage-sensitive chloride channel expressed mainly in the kidney. PMID: 20124441
9. Cardiac signaling genes exhibit unexpected sequence diversity in sporadic cardiomyopathy, revealing HSPB7 polymorphisms associated with disease. PMID: 20038796
10. HSPB7 constitutively localized to SC35 splicing speckles, driven by its N-terminus. Unlike HSPB1 and HSPB5, that chaperoned heat unfolded substrates and kept them folding competent, HSPB7 did not support refolding. PMID: 19464326
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亞細胞定位：

Cytoplasm. Nucleus. Nucleus, Cajal body. Note=Resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles.
蛋白家族：

Small heat shock protein (HSP20) family
組織特異性：

Isoform 1 is highly expressed in adult and fetal heart, skeletal muscle, and at a much lower levels in adipose tissue and in aorta. Undetectable in other tissues. Isoform 2 and isoform 3 are poorly detected in heart.
數據庫鏈接：

HGNC: 5249

OMIM: 610692

KEGG: hsa:27129

STRING: 9606.ENSP00000310111

UniGene: Hs.502612

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