HOXA1 Antibody

說明書

中文名稱：

HOXA1兔多克隆抗體
貨號：

CSB-PA252418
規格：

￥2024
圖片：
Western blot analysis of extracts from COLO cells, HeLa/ cells and 293 cells, using HOXA1 antibody.
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) HOXA1 Polyclonal antibody
Uniprot No.：

P49639
基因名：

HOXA1
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Synthesized peptide derived from internal of Human HOXA1.
免疫原種屬：

Homo sapiens (Human)
克隆類型：

Polyclonal
純化方式：

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度：

It differs from different batches. Please contact us to confirm it.
產品提供形式：

Liquid
應用范圍：

ELISA,WB

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:3000

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Sequence-specific transcription factor. Regulates multiple developmental processes including brainstem, inner and outer ear, abducens nerve and cardiovascular development and morphogenesis as well as cognition and behavior. Also part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures. Seems to act in the maintenance and/or generation of hindbrain segments. Activates transcription in the presence of PBX1A and PKNOX1.
基因功能參考文獻：
1. We speculate that HOXA1 may be the direct target of miR181b5p or miR181d5p in LUSC, and HOXA1 may serve a significant role in nonsmall cell lung cancer (NSCLC) by regulating various pathways, particularly the p53 signaling pathway. PMID: 29658571
2. Study revealed the existence of negative correlation between the expression of miR577 and HOXA1 in hepatocellular carcinoma (HCC) specimens. HOXA1 expression is under the direct regulation of miR577 which is able to bind to its 3'UTR. PMID: 29693150
3. HOTTIP cooperates with CTCF to coordinate HOXA gene expression. PMID: 29698677
4. that miR-433 was frequently downregulated in colon cancer tissues and cell lines. Overexpression of miR-433 significantly inhibited the proliferation and invasion of colon cancer. We also newly identified HOXA1 as a direct target of miR-433. The effects of miR-433 on colon cancer cells were mediated via HOXA1. PMID: 29137689
5. we found that KDM3B exhibits potential tumor-suppressive activity and transcriptionally modulates HOXA1 expression via RARE in AML. PMID: 28540746
6. miR-30c could suppress giant cell tumor of bone cell proliferation and progression via HOXA1, which might provide a new target for giant cell tumor of bone diagnosis and therapy PMID: 29164581
7. UBE2C and HOXA1 RNA and protein are differentially expressed in conventional and Spitz nevi and melanoma. PMID: 28657121
8. Study identified HOXA1 as a direct target of miR-30e. Its expression is down-regulated by miR-30e played leading to suppressed lung cancer cell growth. PMID: 27992364
9. HOXA1-mediated activation of NF-kappaB is non-transcriptional and the RBCK1 and TRAF2 influences on NF-kappaB are epistatic to HOXA1 PMID: 27382069
10. Overexpression of the HOXA1 expression is associated with increased transformation of myelodysplastic syndrome into acute myeloid leukemia. PMID: 26812882
11. Data indicated that HOXA1 and CCND1 mRNA and protein expression were higher in gastric cancer (GC) tissues, that a significant correlation was found between their expression, and they both may serve as a novel prognostic biomarker for GC. PMID: 26791264
12. MicroRNA-99a inhibits tumor aggressive phenotypes through regulating HOXA1 in breast cancer cells. PMID: 26417931
13. In a Middle Eastern population, HOXA1 is not likely a common cause of non-syndromic deafness. PMID: 24878468
14. our findings suggest that HOXA1 is involved in the regulation of prostate cancer progression, including cell growth, migration, invasion and metastasis PMID: 26135141
15. Studied HOTAIR in chemoresistance of SCLC and possible molecular mechanism. Knockdown of HOTAIR was carried out in SCLC multidrug-resistant cell lines; found depletion of HOTAIR reduced HOXA1 methylation by decreasing DNMT1 & DNMT3b expression. PMID: 26707824
16. YAP regulates the expression of HOXA1 and HOXC13 in human keratinocytes. PMID: 25691658
17. Analysis indicates that the genes BIRC5, HOXA1 and RARB are critical targets that play an important regulatory role in cervical cancer pathogenesis. PMID: 25069511
18. ACK1 interacts with KDM3A to regulate the mammary tumor oncogene HOXA1. PMID: 25148682
19. MicroRNA-99 family members suppress Homeobox A1 expression in epithelial cells. PMID: 24312487
20. The results demonstrated that miR-181c transcription is suppressed and HOXA1 expression is enhanced in hepatitis C virus-infected hepatocytes. PMID: 24789793
21. HOXA1-mediated SCLC chemoresistance is under the regulation of miR-100. HOXA1 may be a prognostic predictor and potential therapeutic target in human SCLC PMID: 24559685
22. validation data and mechanistic insights suggest that patients whose primary tumors express HOXA1 are among a high-risk metastasis subgroup that should be considered for anti-TGFbeta therapy in adjuvant settings PMID: 23435427
23. Data indicate that MiR-10a has a role in megakaryocyte differentiation of stem cells via HOXA1 transcription factor targeting. PMID: 23321646
24. The findings in this patient raise the possibility that PTPRN2 may be active during early development of the human brainstem and that its overexpression may cause bilateral Duane retraction syndrome as occurs in patients with homozygous HOXA1 mutations. PMID: 22950449
25. Overexpression of HOXA1 is associated with hepatocellular carcinoma. PMID: 22864671
26. Loss of HOXA1 is associated with pancreatic cancer. PMID: 22407312
27. study demonstrates KDM3A is overexpressed in various types of cancer and directly activates transcription of HOXA1 through demethylation of histone H3K9 by binding to its promoter region PMID: 22020899
28. HOXA1 may contribute to oral carcinogenesis by increasing tumor cell proliferation, and suggest that HOXA1 expression might be helpful as a prognostic marker for patients with oral squamous cell carcinoma. PMID: 22498108
29. the importance of the Hox-Pbx interaction for the oncogenic activity of Hoxa1 PMID: 21957483
30. HOXA1 A218G and HOXB1 nINS/INS variants may not contribute significantly to autism spectrum disorders risk PMID: 21980499
31. the combination of miR-377 and miR-217 help regulate HO-1 protein expression in the presence of hemin PMID: 21106538
32. HOXA1 mutations are not a common cause of sporadic Mobius syndrome in the general population PMID: 20227628
33. It is unlikely that HoxA1 plays a significant role in the genetic predisposition to autism. PMID: 11840501
34. No evidence for linkage of liability to autism to HOXA1 in a sample from the CPEA network PMID: 12210285
35. hoxa1 protein plays a role in the development of infantile autism PMID: 12349873
36. HOXA1 is a human mammary epithelial oncogene with aggressive in vivo tumor formation PMID: 12482855
37. The HOXA1 A218G polymorphism explains approximately 5% of the variance in the head circumference of autistic patients and represents to our knowledge the first known gene variant providing sizable contributions to cranial morphology. PMID: 14960295
38. Mutations in HOXA1 resulting in abnormalities, deafness, facial weakness, hypoventilation, vascular malformations of the internal carotid arteries and cardiac outflow tract, mental retardation and autism spectrum disorder were identified. PMID: 16155570
39. HOXA1 protein with polyhistidine tract expansions misfold, aggregate, and have a toxic effect on cell. PMID: 16168961
40. HOXA1 is a downstream effector of E-cadherin-directed signaling required for anchorage-independent proliferation of mammary carcinoma cells. PMID: 16373333
41. The HOXA1-related syndrome phenotype is variable; HOXA1 mutations are a rare cause of isolated Duane anomaly. PMID: 16528738
42. Study reveals the preferential expression of HOXA1 by metaphase II oocytes. PMID: 16597639
43. Expanded polyhistidine repeats in HOXA1 enhance aggregation and cell death, resulting in impaired neuronal differentiation and cooperative binding with PBX1. PMID: 17131398
44. Variation not associated with autism in an Indian population. PMID: 17167333
45. HOXA1 A218G alleles significantly influence head growth rates, but not final head size, in normal human development. PMID: 17171652
46. Modulation of the p44/42 MAP kinase pathway is one mechanism by which HOXA1 mediates oncogenic transformation of the human mammary epithelial cell. PMID: 17213808
47. This report extends the Bosley-Salih-Alorainy syndrome phenotype and documents the clinical variability resulting from identical HOXA1 mutations within an isolated ethnic population PMID: 17875913
48. Results identified HOXA1 loci showing significant differential DNA methylation levels between tumor and non-tumor lung and highly significant hypermethylation in adenocarcinoma. PMID: 17967182
49. HOXA1 partially mediates oncogenic transformation of the immortalized human mammary epithelial cell through modulation of the STAT3 and STAT5B pathways. PMID: 18276758
50. study describes nine previously unreported individuals from six families who have homozygous mutations of HOXA1 and either the Bosley-Salih-Alorainy syndrome (BSAS) or the Athabascan brainstem dysgenesis syndrome (ABDS) PMID: 18412118
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相關疾病：

Athabaskan brainstem dysgenesis syndrome (ABDS); Bosley-Salih-Alorainy syndrome (BSAS)
亞細胞定位：

Nucleus.
蛋白家族：

Antp homeobox family, Labial subfamily
數據庫鏈接：

HGNC: 5099

OMIM: 142955

KEGG: hsa:3198

STRING: 9606.ENSP00000343246

UniGene: Hs.67397

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