HIP1R Antibody
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中文名稱：HIP1R兔多克隆抗體
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貨號：CSB-PA010366LA01HU
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規(guī)格：￥440
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圖片：
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Western Blot
Positive WB detected in: Rat brain tissue
All lanes: HIP1R antibody at 2.4μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 120, 71 kDa
Observed band size: 120 kDa -
IHC image of CSB-PA010366LA01HU diluted at 1:800 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. -
IHC image of CSB-PA010366LA01HU diluted at 1:800 and staining in paraffin-embedded human pancreatic tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) HIP1R Polyclonal antibody
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Uniprot No.：
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基因名：HIP1R
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別名：FLJ14000 antibody; FLJ27022 antibody; HIP-12 antibody; Hip1 related antibody; HIP1-related protein antibody; HIP12 antibody; HIP1R antibody; HIP1R_HUMAN antibody; HIP3 antibody; Huntingtin Interacting Protein 1 Related antibody; Huntingtin interacting protein 12 antibody; Huntingtin-interacting protein 1-related protein antibody; Huntingtin-interacting protein 12 antibody; ILWEQ antibody; KIAA0655 antibody; MGC47513 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human, Rat
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免疫原：Recombinant Human Huntingtin-interacting protein 1-related protein (304-487AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產(chǎn)品，HIP1R Antibody (CSB-PA010366LA01HU)，的標記方式是Non-conjugated。對于HIP1R Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB, IHC
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:5000 IHC 1:500-1:1000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
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基因功能參考文獻：
- HIP1R rescued miR-23b/-27b-mediated repression of migration in prostate cancer cells. HIP1R mRNA levels were decreased in seminal vesicle tissue from mice bearing miR-23b/-27b-transduced prostate cancer cell xenografts compared with scrambled controls, suggesting HIP1R is a key functional target of miR-23b/-27b. PMID: 26898757
- our findings support the conclusion that the rs12817488 in CCDC62/HIP1R polymorphism may increase the risk of Parkinson's disease in the Chinese Han population. PMID: 25818163
- We conclude that HIP1R expression is strongly indicative of survival in diffuse large B-cell lymphoma PMID: 26341140
- STK39 (rs2102808) and CCDC62/HIP1R (rs12817488) do not appear to influence PD risk. PMID: 24312176
- HIP1r plays an important role in regulating the attachment of spindle microtubules to chromosomes during mitosis, an event that is required for accurate congression and segregation of chromosomes. PMID: 21189155
- HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin. Identification of a novel interaction with clathrin light chain. (HIP12) PMID: 11889126
- both HIP1r and HIP1 bind inositol lipids via their epsin N-terminal homology (ENTH) domains PMID: 14732715
- Hip1R has a role in making the interaction between actin and the endocytic machinery functional and transient PMID: 14742709
- The F-actin binding capacity of Hip12 is regulated by intrasteric occlusion of primary actin-binding determinants within the Hip12 I/LWEQ module. PMID: 15581353
- the stability of intergenerational transmission of a variable number tandem repeat (VNTR) polymorphism, found in the Huntingtin interacting protein-1 related gene (HIP12/HIP1R) that is mapped to the chromosome 12q24.31 region. PMID: 15588756
- characterize the F-actin-binding region of HIP1R, termed the talin-HIP1/R/Sla2p actin-tethering C-terminal homology (THATCH) domain PMID: 16415883
- Human HIP1 transgenic Hip1/Hip1r knockout mice are completely free from dwarfism and spinal defects. PMID: 17452370
- Neuronal dysfunction in transgenic Caenorhabditis elegans expressing mutant N-terminal huntingtin is specifically enhanced by hipr-1 loss of function. PMID: 17928447
- in mammalian cells CLCs function in intracellular membrane trafficking by acting as recruitment proteins for HIP1R, enabling HIP1R to regulate actin assembly on clathrin-coated structures PMID: 18165318
- Actin binding by Hip1 (huntingtin-interacting protein 1) and Hip1R (Hip1-related protein) is regulated by clathrin light chain PMID: 18790740
- This study provided the previously unknown function of HIP1R involved in the intrinsic cell death pathway and further explored possible mechanisms by which HIP1R induces cell death. PMID: 19255499
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亞細胞定位：Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
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蛋白家族：SLA2 family
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組織特異性：Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.
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數(shù)據(jù)庫鏈接：
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