GPRC6A Antibody
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中文名稱：GPRC6A兔多克隆抗體
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貨號：CSB-PA722571LA01HU
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規(guī)格：￥440
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圖片：
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Western Blot
Positive WB detected in: HepG2 whole cell lysate, PC-3 whole cell lysate
All lanes: GPRC6A antibody at 1:500
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 105, 85, 97 kDa
Observed band size: 105 kDa -
IHC image of CSB-PA722571LA01HU diluted at 1:50 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. -
Immunofluorescence staining of PC-3 cells with CSB-PA722571LA01HU at 1:100, counter- stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). -
Immunofluorescence staining of Hela cells with CSB-PA722571LA01HU at 1:100, counter- stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) GPRC6A Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：bA86F4.3 antibody; G protein coupled receptor 33 antibody; G protein coupled receptor family C group 6 member A antibody; G-protein coupled receptor family C group 6 member A antibody; G-protein coupled receptor GPCR33 antibody; GPC6A_HUMAN antibody; GPCR 33 antibody; GPCR 6A antibody; GPCR antibody; GPCR33 antibody; GPCR6A antibody; GPR C6A antibody; GPRC 6A antibody; gprc6a antibody; hGPCR 33 antibody; hGPCR33 antibody; hGPRC6A antibody; OTTHUMP00000017075 antibody; Predicted with SOSUI analysis antibody; seven transmembrane helix receptor antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human G-protein coupled receptor family C group 6 member A protein
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
本頁面中的產(chǎn)品，GPRC6A Antibody (CSB-PA722571LA01HU)，的標(biāo)記方式是Non-conjugated。對于GPRC6A Antibody，我們還提供其他標(biāo)記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen affinity purification
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB, IHC, IF
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 IHC 1:200-1:500 IF 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價
相關(guān)產(chǎn)品
靶點詳情
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功能：Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalcin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinate nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalent ions and its responsiveness to anabolic steroids.
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基因功能參考文獻：
- If the regulatory functions of GPRC6A identified in mice translate to humans, and polymorphisms in GPRC6A are found to predict racial disparities in human diseases, GPRC6A may be a new gene target to predict, prevent, and treat MetS, PCa, and other disorders impacted by GPRC6A. PMID: 28180060
- Human GPRC6A is a functional osteocalcin and testosterone sensing receptor that promotes prostate cancer progression. PMID: 28659174
- he nonrare polymorphism rs2274911 in the GPRC6A gene was associated with insulin resistance features, independently of the metabolic phenotype and osteocalcin levels. PMID: 27696500
- Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function PMID: 27986810
- Osteocalcin and Sex Hormone Binding Globulin Compete on a Specific Binding Site of GPRC6A. PMID: 27673554
- results suggest that G protein-coupled receptor class C group 6 member A(GPRC6A) inactivation or sub-function contributes to reduced exposure to androgens, leading to cryptorchidism during fetal life and/or low sperm production in adulthood PMID: 26735260
- association of the THADA, FOXP4, GPRC6A/RFX6 and 8q24 genes with prostate cancer in Asian populations. PMID: 26537068
- The present experiments demonstrated a critical role for the GPRC6A-ERK1/2 and PI3K/Akt signaling pathway in arginine-mediated fibroblast survival. PMID: 24651445
- Duox1 activity is stimulated by testosterone through GPRC6A in skin keratinocytes PMID: 25164816
- The F464Y substitution in GPRC6A may be a cause of primary testicular failure. PMID: 23728177
- Extracellular Ca2+ activates the NLRP3 inflammasome via CaSR and GPRC6A. PMID: 23271661
- the GPRC6A receptor functions as an amino acid sensor in GLUTag cells that promotes GLP-1 secretion PMID: 23269670
- Our results provide further support for association of the C2orf43, FOXP4, GPRC6A and RFX6 genes with prostate cancer in Eastern Asian populations PMID: 22662242
- GPRC6A is a novel molecular target for regulating prostate growth and cancer progression. PMID: 21681779
- Observational study of gene-disease association. (HuGE Navigator) PMID: 20654748
- Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20676098
- that GPRC6A gene polymorphisms were significantly associated with human spine BMD. PMID: 19874200
- GPRC6A is widely expressed in brain and peripheral tissues with highest levels in kidney, skeletal muscle, testis, and leucocytes. PMID: 15194188
- elucidating agonist interaction with GPRC6A, a novel family C G-protein-coupled receptor. PMID: 15576628
- GPRC6A is a cation-, calcimimetic-, and osteocalcin-sensing receptor PMID: 16199532
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亞細胞定位：Cell membrane; Multi-pass membrane protein.
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蛋白家族：G-protein coupled receptor 3 family
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組織特異性：Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detec
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