GNG2 Antibody
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中文名稱：GNG2兔多克隆抗體
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貨號：CSB-PA009614OA01HU
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規格：￥440
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圖片：
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IHC image of CSB-PA009614OA01HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. -
IHC image of CSB-PA009614OA01HU diluted at 1:100 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. -
Immunofluorescence staining of U251 cells with CSB-PA009614OA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) GNG2 Polyclonal antibody
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Uniprot No.：
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基因名：
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別名：G gamma I antibody; G gamma-I antibody; GBG2_HUMAN antibody; GNG 2 antibody; Gng2 antibody; Guanine nucleotide binding protein gamma 2 antibody; Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Peptide sequence from Human Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 protein (44-62AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，GNG2 Antibody (CSB-PA009614OA01HU)，的標記方式是Non-conjugated。對于GNG2 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, IHC, IF
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 IF 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
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基因功能參考文獻：
- High GNG2 expression is associated with alcoholic hepatitis. PMID: 28818508
- G-protein betagamma subunits are positive regulators of Kv7.4 and native vascular Kv7 channel activity. PMID: 25941381
- Alteration of gene expression profiling including GPR174 and GNG2 is associated with vasovagal syncope. PMID: 25367286
- Data indicate that endogenous mTOR interacts with Gbetagamma. PMID: 24462769
- increased protein expression level of GNG2 alone inhibits proliferation of malignant melanoma cells in vitro and in vivo PMID: 23031273
- presence of Gng2 and Netrin-G2 immunoreactive elements in the insular cortex, but not in the putamen, suggests a possible common ontogeny of the claustrum and insula PMID: 22957104
- Gbetagamma inhibits Epac-induced Ca 2+ elevation in melanoma cells. Cross talk of Ca 2+ signaling between Gbetagamma & Epac plays a major role in melanoma cell migration. PMID: 21679469
- Data implicate the domain I-II linker region as an important contributor to voltage dependent Gbeta1/Ggamma2 modulation of Cav2.2 calcium channels. PMID: 20181083
- Data show that activation of PLCbeta(2) by alpha(q) and beta1gamma2 differ from activation by Rac2 and from each other. PMID: 20007712
- Data show that G protein inhibition of N-type calcium channels is critically dependent on two separate but adjacent approximately 20-amino acid regions of the Gbeta subunit, as examined with Gbetas 1 and 5 and Ggamma2. PMID: 15105422
- 10 genes were down-regulated following treatment of the T-ALL cells with 0.15 and 1.5 microg/mL of metal ores at 72 h PMID: 15747776
- Fission of transport carriers at the trans-Golgi network is dependent on specifically PLCbeta3, which is necessary to activate PKCeta and PKD in that Golgi compartment, via diacylglycerol production. PMID: 17492941
- signaling pathway by which G(i)-coupled receptor specifically induces Rac and Cdc42 activation through direct interaction of Gbetagamma with FLJ00018. PMID: 18045877
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亞細胞定位：Cell membrane; Lipid-anchor; Cytoplasmic side.
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蛋白家族：G protein gamma family
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組織特異性：Expressed in fetal tissues, including testis, adrenal gland, brain, white blood cells and brain.
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數據庫鏈接：
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