GCHFR Antibody, Biotin conjugated

說明書

中文名稱：

GCHFR兔多克隆抗體, Biotin偶聯
貨號：

CSB-PA009318LD01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) GCHFR Polyclonal antibody
Uniprot No.：

P30047
基因名：

GCHFR
別名：

GCHFR antibody; GFRP antibody; GFRP_HUMAN antibody; GTP cyclohydrolase 1 feedback regulatory protein antibody; GTP cyclohydrolase I feedback regulator antibody; GTP cyclohydrolase I feedback regulatory protein antibody; HsT16933 antibody; MGC138467 antibody; MGC138469 antibody; p35 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human GTP cyclohydrolase 1 feedback regulatory protein (11-55AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Biotin
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.
基因功能參考文獻：
1. homozygous individuals for the TT haplotype were less likely to respond to the SSRI fluoxetine than to the nortriptyline suggesting a biological process through which GCHFR promoter variants might influence antidepressant response. PMID: 20351752
2. Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein PMID: 11799107
3. allosteric regulation of GTPCH-I activity in the cardiovascular system maybe an important mechanism regulating BH4 levels through GTPCH-I feedback regulatory protein signaling PMID: 15649650
4. GFRP/GTPCHI axis functions in epidermal keratinocytes and melanocytes in the cytosol and nucleus. PMID: 16778797
5. GCH1 mutations in Japanese patients with DYT5 dystonia. In some of them, the GCH1 enzyme activity was proved to be impaired. PMID: 17101830
6. The co-expression of GTP cyclohydrolase I (GCHI) with tyrosine hydroxylase (TH) indicates that TH is indeed active in human neurosecretory neurons. PMID: 17135716
7. Demonstrate role for GFRP in regulating iNOS-mediated NO synthesis and suggest that the allosteric regulation of GTP-CH1 activity by GFRP may be an important mechanism regulating BH(4) and NO levels in vivo. PMID: 18372436
8. crystal structure PMID: 11580249
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亞細胞定位：

Nucleus. Nucleus membrane. Cytoplasm, cytosol.
蛋白家族：

GFRP family
組織特異性：

In epidermis, expressed predominantly in basal undifferentiated keratinocytes and in some but not all melanocytes (at protein level).
數據庫鏈接：

HGNC: 4194

OMIM: 602437

KEGG: hsa:2644

STRING: 9606.ENSP00000260447

UniGene: Hs.631717

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