GAS2 Antibody

說明書

產品詳情

Uniprot No.：

O43903
基因名：

GAS2
別名：

GAS 2 antibody; GAS-2 antibody; Gas2 antibody; GAS2_HUMAN antibody; Growth arrest specific 2 antibody; Growth arrest specific protein 2 antibody; Growth arrest-specific protein 2 antibody; MGC32610 antibody
宿主：

Rabbit
反應種屬：

Human,Mouse,Rat
免疫原：

Human GAS2
免疫原種屬：

Homo sapiens (Human)
抗體亞型：

IgG
純化方式：

Antigen Affinity Purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
產品提供形式：

Liquid
應用范圍：

ELISA,WB,IHC
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process.
基因功能參考文獻：
1. Taken together, our results demonstrated the deregulation of GAS2 in both AML and ALL and the requirement of GAS2-Calpain2 axis for the growth of leukemic cells. PMID: 26358320
2. Truncated HBx deregulates cell growth via direct silencing of GAS2 and thereby provides a survival advantage for pre-neoplastic hepatocytes to facilitate cancer development via TP53 signaling. PMID: 25925944
3. GAS2 is up-regulated in chronic myeloid leukemia cells. PMID: 24465953
4. Studies have identified a Gas2/calpain-dependent mechanism by which ICSBP influences beta-catenin activity in myeloid leukemia. PMID: 20679491
5. Gas2DN can increase the activity of calpain and induce degradation of stabilized/mutated beta-catenin PMID: 15817486
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亞細胞定位：

Cytoplasm, cytoskeleton, stress fiber. Membrane; Peripheral membrane protein.
蛋白家族：

GAS2 family
組織特異性：

Ubiquitously expressed with highest levels in liver, lung, and kidney. Not found in spleen.
數據庫鏈接：

HGNC: 4167

OMIM: 602835

KEGG: hsa:2620

STRING: 9606.ENSP00000278187

UniGene: Hs.711297

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