GABRA6 Antibody
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中文名稱：GABRA6兔多克隆抗體
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貨號(hào)：CSB-PA002619
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規(guī)格：￥1090
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圖片：
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Western Blot analysis of MOUSE-BRAIN cells using GABAA Rα6 Polyclonal Antibody -
Western Blot analysis of MOUSE-BRAIN cells using GABAA Rα6 Polyclonal Antibody
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其他：
產(chǎn)品詳情
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Uniprot No.：
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基因名：
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別名：GABA A antibody; GABA A Receptor alpha 6 polypeptide antibody; GABA A receptor alpha 6 antibody; GABA A receptor subunit alpha 6 antibody; GABA subunit A receptor alpha 6 antibody; GABA(A) receptor subunit alpha-6 antibody; GABRA 6 antibody; GABRA6 antibody; Gamma aminobutyric acid A receptor alpha 6 antibody; Gamma aminobutyric acid GABA A receptor alpha 6 antibody; Gamma aminobutyric acid receptor subunit alpha 6 antibody; Gamma-aminobutyric acid receptor subunit alpha-6 antibody; GBRA6_HUMAN antibody; MGC116903 antibody; MGC116904 antibody
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宿主：Rabbit
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反應(yīng)種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the Internal region of Human GABAA Rα6.
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:40000 -
Protocols：
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儲(chǔ)存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
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基因功能參考文獻(xiàn)：
- TMEM132D, COMT and GABRA6 gene polymorphisms may influence susceptibility to panic disorder(PD) and major depressive disorder(MDD)in Japanese adults; these variants may increase vulnerability to PD by modulating oligodendrocytes and GABA and dopaminergic functions in related brain regions, altering neuronal processing of anxiety-related emotional signals PMID: 25974322
- NOS3, GABRA6, child abuse, neighborhood crime Gene x Gene, Environment x Environment, and Gene x Environment interactions are associated with different patterns of respiratory sinus arrhythmia reactivity. PMID: 26535938
- The gene-gene interaction at two loci involving GABRA6 and Synapsin II revealed a significant association for development of idiopathic generalized epilepsy. PMID: 25088614
- genetic association study in Chinese Han population: Data suggest an SNP in GABRA6 (rs3219151) is associated with decreased predisposition to schizophrenia via alteration of miroRNA binding to target in 3-prime-untranslated region of GABRA6 mRNA. PMID: 23332465
- GABRA6 mutation, R46W, was identified as a susceptibility gene that may contribute to the pathogenesis of childhood absence epilepsy and cause neuronal disinhibition and increase in seizures via a reduction of alphabetagamma and alphabetadelta receptor function and expression PMID: 21930603
- Part of the interindividual differences observed for anxiety traits measured by the Harm Avoidance dimension could be explained by the GABRA6 gene variability. PMID: 21902679
- significant involvement of alpha (GABRA6) and beta (GABRB2) subunits of GABA(A) receptor in epilepsy susceptibility in north Indian population PMID: 21420396
- studies have found prefrontal cortical GABA(A) receptor alpha subunit alterations in schizophrenia PMID: 20100621
- These findings support a role for the serotonin transporter and GABA(A) alpha6 subunit in depression-related traits. PMID: 14744464
- The T1521C polymorphism in the GABRA6 gene is associated with specific personality characteristics as well as a marked attenuation in hormonal and blood pressure responses to psychological stress. PMID: 15197399
- GABRA6 expression is regulated by NFI in cerebellar granule neurons PMID: 15466411
- Findings support a role for GABRA6 (Pro385Ser) in perceived parenting. PMID: 16402352
- Polymorphism not associated with panic disorder. PMID: 17167337
- Chinese patients with certain psychiatric characteristics and GABRA6 heterozygosity are probably predisposed to functional heartburn PMID: 17295876
- The T allele of the 1519T>C GABA(A)alpha6 gene may be one of the modulating factors associated with changes in craving for alcohol and food during treatment of patients with alcohol dependence. PMID: 18616664
- Significant matching effects were found for polymorphisms at the DRD2, GABRA6 and GABRB2 gene. In addition, a trend was found for the OPRM1 polymorphism. PMID: 19523047
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亞細(xì)胞定位：Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
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蛋白家族：Ligand-gated ion channel (TC 1.A.9) family, Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily, GABRA6 sub-subfamily
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