EFHD2 Antibody, Biotin conjugated
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中文名稱：EFHD2兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA856907LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) EFHD2 Polyclonal antibody
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Uniprot No.：
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基因名：EFHD2
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別名：EF hand domain containing protein 2 antibody; EF hand domain family; member D2 antibody; EF-hand domain-containing protein D2 antibody; EFHD 2 antibody; EFHD2 antibody; EFHD2_HUMAN antibody; RP3-467K16.3 antibody; Swiprosin 1 antibody; Swiprosin-1 antibody; SWS1 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human EF-hand domain-containing protein D2 protein (2-240AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance.
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基因功能參考文獻：
- Data demonstrate that EFhd2 shows unique structural and biological features as an EF-hand containing F-actin bundling protein. For F-actin bundling activity, structural stabilization of the EF-hand domains was found to occur in the presence of Ca2+. The core region of EFhd2 maintains its structure in the absence of Ca2+ ; however, changes in local conformational flexibility reduce F-actin bundling activity of EFhd2. PMID: 27974828
- Phosphorylation at Ser183 of EFhd2 causes changes in the local conformational dynamics and the surface charge distribution of the actin-binding site, resulting in a re-coordination of the actin-binding sites in the dimer structure. PMID: 28011271
- The results imply that EFhd2's physiological and/or pathological function could be regulated by its phosphorylation state. PMID: 24917152
- EFhd2 is involved in the control of synapse development and maintenance and is linked to dementia. PMID: 25383639
- Swiprosin-1 localizes to microvilli-like membrane protrusions and lamellipodia and exhibits actin-binding activity. PMID: 23977092
- Swiprosin-1 is involved in regulating the accessibility of F-actin to cofilin through the clustering of F-actin and the activity of Swiprosin-1 is highly dependent on its phosphorylation status at Ser183 PMID: 23959172
- EFhd2 may play an important role in the pathobiology of tau-mediated neurodegeneration. PMID: 23331044
- the human Shu complex (hSWS1.SWSAP1) has an evolutionarily conserved function in homologous recombination PMID: 21965664
- This protein has been found differentially expressed in thalami from patients with schizophrenia. PMID: 20471030
- Its predominant presence in CD8 lymphocytes suggests that swiprosin-1 may be involved in functions that are important for cytotoxic lymphocytes. PMID: 15274114
- These results suggest that swiprosin-1 is a PKC-beta I/eta-inducible gene and it modulates mast cell activation through NF-kappaB-dependent pathway. PMID: 19693767
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亞細胞定位：Membrane raft.
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組織特異性：Found in lymphocytes; preferentially expressed in CD8+ cells.
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數據庫鏈接：
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