ECD Antibody, HRP conjugated

說明書

中文名稱：

ECD兔多克隆抗體, HRP偶聯
貨號：

CSB-PA007370LB01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ECD Polyclonal antibody
Uniprot No.：

O95905
基因名：

ECD
別名：

ecd antibody; ECD_HUMAN antibody; Ecdysoneless homolog antibody; hSGT1 antibody; Human suppressor of GCR two antibody; Protein ecdysoneless homolog antibody; SGT 1 antibody; SGT1 protein antibody; Suppressor of GCR2 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Protein ecdysoneless homolog protein (1-300AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

HRP
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA
Protocols：

ELISA Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP. May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes. Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins. The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex. May play a role in regulation of pre-mRNA splicing.
基因功能參考文獻：
1. The interaction of ECD with RUVBL1, and its CK2-mediated phosphorylation, independent of its interaction with PIH1D1, are important for its cell cycle regulatory function. PMID: 26711270
2. Ecdysoneless and H-Ras expressing human mammary epithelial cells form tumors in NOD/SCID mice. PMID: 25616580
3. Ecd is a novel tumor-promoting factor that is differentially expressed in pancreatic cancer and potentially regulates glucose metabolism within cancer cells. PMID: 22977192
4. Ecd as a novel marker for breast cancer progression and show that levels of Ecd expression predict poorer survival in Her2/neu overexpressing breast cancer patients. PMID: 22270930
5. Ecd localizes to both nucleus & cytoplasm & shuttles between the nucleus and cytoplasm; however, it exhibits strong nuclear export. Based on previous yeast studies & evidence provided here, we suggest that Ecd functions as a transcriptional regulator. PMID: 19919181
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亞細胞定位：

Cytoplasm. Nucleus.
蛋白家族：

ECD family
組織特異性：

Highly expressed in muscle and heart. Over-expressed in pancreatic and breast cancers.
數據庫鏈接：

HGNC: 17029

OMIM: 616464

KEGG: hsa:11319

STRING: 9606.ENSP00000401566

UniGene: Hs.631822

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