Dop1R1 Antibody

^{Rare Species}

說明書

中文名稱：

Dop1R1兔多克隆抗體
貨號：

CSB-PA334865XA01DLU
規(guī)格：

￥440
圖片：
Western Blot
Positive WB detected in Recombinant protein
All lanes: Dop1R1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 31 kDa
Observed band size: 31 kDa
其他：

產(chǎn)品詳情
產(chǎn)品評價
相關產(chǎn)品
靶點詳情

產(chǎn)品詳情

Uniprot No.：

P41596
基因名：

Dop1R1
別名：

Dopamine receptor 1 (D-DOP1) (DmDop1) (dDA1) (Dopamine 1-like receptor 1) Dop1R1 DopR DopR1 DopR35EF CG9652
反應種屬：

Drosophila melanogaster (Fruit fly)
免疫原：

Recombinant Drosophila melanogaster (Fruit fly) Dop1R1 protein (20-142aa )
免疫原種屬：

Drosophila melanogaster (Fruit fly)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Protein G
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA, WB
Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

功能：

Receptor for dopamine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Might be involved in the processing of visual information and/or visual learning. Important for Pavlovian conditioning: required in the mushroom body as a receptor conveying unconditional stimuli information, has a role in memory formation for aversive and appetitive learning. Sleep-deprivation-induced impairments in learning can be partially explained through alterations in dopamine signaling, Dop1R1 expression levels are reduced; sleep may have a role in restoring dopamine homeostasis.
基因功能參考文獻：
1. It is concluded that the activating effect of dopamine on JH(juvenile hormone) synthesis in Drosophila is mediated by D1-like receptors PMID: 23035552
2. a dopamine D1-like receptor, DopR, was involved in fly courtship behavior. DopR mutant male flies display male-male courtship behavior. PMID: 22683328
3. Juvenile hormone synthesis is stimulated by activation of dopamine D1-like receptors in Drosophila. PMID: 22218953
4. D1 dopamine receptor dDA1 is required in the mushroom body neurons for aversive and appetitive learning in Drosophila. PMID: 17634358
5. All our data demonstrated that activation of D1-like receptors in Drosophila neurons negatively modulates excitatory cholinergic synaptic transmission and thus inhibits neuronal excitability. PMID: 17986026
6. This review provides evidence that dopamine D1 receptor DopR is involved in several types of attentional processes and independently regulates distinct types of arousal. PMID: 19945386
7. Loss-of-function mutations in the D1 dopamine receptor DopR enhance repetitive startle-induced arousal while decreasing sleep-wake arousal. PMID: 19945394
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亞細胞定位：

Cell membrane; Multi-pass membrane protein.
蛋白家族：

G-protein coupled receptor 1 family
組織特異性：

Expressed in the larval and adult CNS in structures that mediate higher-order brain functions such as learning, memory and motor control: in the mushroom body neuropil and four unpaired neurons in each thoracic segment. The adult CNS has intense expressio
數(shù)據(jù)庫鏈接：

KEGG: dme:Dmel_CG9652

STRING: 7227.FBpp0303554

UniGene: Dm.3077

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