DOCK10 Antibody, Biotin conjugated
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中文名稱：DOCK10兔多克隆抗體, Biotin偶聯
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貨號：CSB-PA842645LD01HU
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規格：￥880
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) DOCK10 Polyclonal antibody
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Uniprot No.：
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基因名：DOCK10
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別名：DOCK10 antibody; KIAA0694 antibody; ZIZ3Dedicator of cytokinesis protein 10 antibody; Zizimin-3 antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Dedicator of cytokinesis protein 10 protein (1645-2186AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Biotin
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA
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Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression.
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基因功能參考文獻：
- T cells and B cells exhibited inverse expression patterns of the DOCK10 isoforms PMID: 21514340
- Dock10 could represent a point of convergence for interleukin 4 signalling and small Rho GTPase function in B cells. PMID: 18499258
- Silencing DOCK10 expression in melanoma promotes conversion to mesenchymal migration and is associated with decreased MLC2 phosphorylation and increased Rac1 activation. PMID: 18835169
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亞細胞定位：Nucleus. Cytoplasm. Cell projection, dendritic spine.
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蛋白家族：DOCK family
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組織特異性：Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells.
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數據庫鏈接：
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