COASY Antibody

中文名稱：

COASY兔多克隆抗體
貨號：

CSB-PA618754LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: Hela whole cell lysate, HEK293 whole cell lysate
All lanes: COASY antibody at 3.4μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 63, 66 kDa
Observed band size: 63, 66 kDa

Immunofluorescent analysis of Hela cells using CSB-PA618754LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) COASY Polyclonal antibody
Uniprot No.：

Q13057
基因名：

COASY
別名：

Bifunctional coenzyme A synthase antibody; Bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase antibody; CoA synthase antibody; COASY antibody; COASY_HUMAN antibody; Coenzyme A synthase antibody; Dephospho-CoA kinase antibody; Dephospho-CoA pyrophosphorylase antibody; Dephosphocoenzyme A kinase antibody; DPCK antibody; DPCOAK antibody; NBP antibody; Nucleotide binding protein antibody; Pantetheine-phosphate adenylyltransferase antibody; Phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase antibody; pOV 2 antibody; POV-2 antibody; POV2 antibody; PPAT antibody; UKR1 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Bifunctional coenzyme A synthase protein (453-546AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，COASY Antibody (CSB-PA618754LA01HU)，的標記方式是Non-conjugated。對于COASY Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA618754LB01HU	COASY Antibody, HRP conjugated	ELISA
FITC	CSB-PA618754LC01HU	COASY Antibody, FITC conjugated
Biotin	CSB-PA618754LD01HU	COASY Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IF	1:50-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation.
基因功能參考文獻：
1. The recruitment of COASY inhibits CBP-mediated TPX2 acetylation, promoting TPX2 degradation for mitotic exit. PMID: 29531224
2. The COASY protein contains a mitochondrial localization signal, a regulatory region and a domain for each of the two catalytic kinase domains: adenyl transferase and dephospho CoA PMID: 27021474
3. DNA methylation levels in the COASY and SPINT1 promoter regions were considered to potentially be a convenient and useful biomarker for diagnosis of Alzheimer's Disease and Amnestic Mild Cognitive Impairment. PMID: 27992572
4. Exome sequencing revealed the presence of recessive missense mutations in COASY, encoding coenzyme A (CoA) synthase in neurodegeneration with brain iron accumulation PMID: 24360804
5. EDC4 might contribute to regulation of CoA biosynthesis in addition to its scaffold function in processing bodies PMID: 22982864
6. Identification and characterization of the gene encoding the human phosphopantetheine adenylyltransferase and dephospho-CoA kinase bifunctional enzyme (CoA synthase). PMID: 11994049
7. description of the existence of a novel CoA synthase isoform, which is the product of alternative splicing and possesses a 29aa extension at the N-terminus; termed it CoASy beta PMID: 16460672
8. CoA synthase is involved in signaling events in the cell and forms a functional complex with p85alphaPI3K in vivo. PMID: 19482007
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相關疾病：

Neurodegeneration with brain iron accumulation 6 (NBIA6)
亞細胞定位：

Cytoplasm. Mitochondrion matrix.
蛋白家族：

Eukaryotic CoaD family
組織特異性：

Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liv
數據庫鏈接：

HGNC: 29932

OMIM: 609855

KEGG: hsa:80347

STRING: 9606.ENSP00000464814

UniGene: Hs.296422

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