CHP2 Antibody
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中文名稱：CHP2兔多克隆抗體
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貨號：CSB-PA001642
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規格：￥1090
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圖片：
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Western Blot analysis of Jurkat cells using CHP2 Polyclonal Antibody
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其他：
產品詳情
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Uniprot No.：
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基因名：CHP2
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別名：CHP2 antibody; HCA520Calcineurin B homologous protein 2 antibody; Hepatocellular carcinoma-associated antigen 520 antibody
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宿主：Rabbit
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反應種屬：Human,Mouse,Rat
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免疫原：Synthesized peptide derived from the Internal region of Human CHP2.
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
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抗體亞型：IgG
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純化方式：The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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產品提供形式：Liquid
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應用范圍：WB, ELISA
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推薦稀釋比：
Application Recommended Dilution WB 1:500-1:2000 ELISA 1:40000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
相關產品
靶點詳情
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功能：Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus.
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基因功能參考文獻：
- CHP2 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
- chp2 expression in leukemia primary cells and leukemia cell lines is significantly increased. PMID: 18718049
- These findings suggest that CHP serves as an obligatory subunit that is required both for supporting the basic activity and regulating the pH-sensing of NHE1 via interactions between distinct parts of these proteins. PMID: 16710297
- overexpression of the CHP2 gene affects the biological behavior of ovarian cancer cell line OVCAR3 and is one of key mechanisms for ovarian carcinoma progression PMID: 17708351
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亞細胞定位：Nucleus. Cytoplasm. Cell membrane.
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蛋白家族：Calcineurin regulatory subunit family, CHP subfamily
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組織特異性：Expressed in malignantly transformed cells but not detected in normal tissues.
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數據庫鏈接：
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