CCT3 Antibody

說明書

產(chǎn)品詳情

產(chǎn)品名稱：

Rabbit anti-Homo sapiens (Human) CCT3 Polyclonal antibody
Uniprot No.：

P49368
基因名：

CCT3
別名：

CCT 3 antibody; CCT gamma antibody; CCT-gamma antibody; CCT3 antibody; CCTG antibody; Chaperonin containing TCP1 subunit 3 (gamma) antibody; Chaperonin containing TCP1 subunit 3 antibody; hTRiC5 antibody; PIG48 antibody; T complex protein 1 gamma subunit antibody; T complex protein 1 subunit gamma antibody; T-complex protein 1 subunit gamma antibody; TCP 1 gamma antibody; TCP-1-gamma antibody; TCP1 (t complex 1) ring complex polypeptide 5 antibody; TCPG_HUMAN antibody; TRIC5 antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human T-complex protein 1 subunit gamma protein (1-300AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

Non-conjugated
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

Antigen Affinity purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
產(chǎn)品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
基因功能參考文獻：
1. Suggest that CCT3 is indispensible for hepatocellular carcinoma cell proliferation, and provides a potential drug target for treatment of HCC. PMID: 26739059
2. Overexpression of CCT3 in the nuclei of cancerous cells is associated with hepatocellular carcinoma progression. CCT3 may be a target that affects the activation of STAT3 in HCC. PMID: 26229401
3. Expression of S100A9 and CCTgamma was significantly elevated in liver tissue of patients with cholangiocarcinoma compared with controls. PMID: 23868055
4. Among ten hepatocellular carcinoma cases with amplicon 1q21-q22, significant gene expression level of JTB, SHC1, CCT3 and COPA in the tumors than the paired adjacent non-malignant liver tissues. PMID: 12586295
亞細胞定位：

Cytoplasm.
蛋白家族：

TCP-1 chaperonin family
數(shù)據(jù)庫鏈接：

HGNC: 1616

OMIM: 600114

KEGG: hsa:7203

STRING: 9606.ENSP00000295688

UniGene: Hs.491494

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