CCHCR1 Antibody

中文名稱：

CCHCR1兔多克隆抗體
貨號：

CSB-PA004769LA01HU
規格：

￥440
圖片：
Western Blot
Positive WB detected in: 293T whole cell lysate, 293 whole cell lysate, HepG2 whole cell lysate, THP-1 whole cell lysate, U251 whole cell lysate
All lanes: CCHCR1 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 89, 100, 96 kDa
Observed band size: 89 kDa

IHC image of CSB-PA004769LA01HU diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.

Immunofluorescence staining of U251 cells with CSB-PA004769LA01HU-IF at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CCHCR1 Polyclonal antibody
Uniprot No.：

Q8TD31
基因名：

CCHCR1
別名：

Coiled-coil alpha-helical rod protein 1 (Alpha-helical coiled-coil rod protein) (Putative gene 8 protein) (Pg8), CCHCR1, C6orf18 HCR
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Coiled-coil alpha-helical rod protein 1 protein (281-500aa)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CCHCR1 Antibody (CSB-PA004769LA01HU)，的標記方式是Non-conjugated。對于CCHCR1 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA004769LB01HU	CCHCR1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA004769LC01HU	CCHCR1 Antibody, FITC conjugated
Biotin	CSB-PA004769LD01HU	CCHCR1 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:100-1:500
IF	1:100-1:500

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

May be a regulator of keratinocyte proliferation or differentiation.
基因功能參考文獻：
1. psoriasis candidate gene CCHCR1 expressed at P-bodies and centrosomes PMID: 29866042
2. CCHCR1 interacts specifically with the E2 protein of human papillomavirus type 16 on a surface overlapping BRD4 binding PMID: 24664238
3. Confocal imaging confirmed the localization of CCHCR1 in P-bodies. PMID: 24858563
4. The centrosomal localization of CCHCR1 provides a connection to the abnormal cell proliferation and offers a link to possible cellular pathways altered in psoriasis. PMID: 23189171
5. Psoriasis is associated with genetic polymorphism in the CCHCR1 gene and in a genomic segment flanking the HLA-C region in the North Indian population. PMID: 22182809
6. Isolated by a two hybrid assay, StAR binding protein binds StAR protein in cells and enhances the ability of StAR protein to promote syntheses of steroid hormones.(sTAR binding protein) PMID: 12909641
7. These studies show that miR-122, a 22-nucleotide microRNA, is derived from a liver-specific noncoding polyadenylated RNA transcribed from the gene hcr. PMID: 17179747
8. These results suggest a role for CCHCR1 in the pathogenesis of psoriasis via the regulation of skin steroid metabolism. PMID: 17221218
9. Results show that HLA-Cw6 and CCHCR1 risk allele associations with clinical features of psoriasis are predictably highly similar in a Finnish nationwide cohort of 379 psoriasis patients. PMID: 17340018
10. the aberrant function of CCHCR1 may lead to abnormal keratinocyte proliferation which is a key feature of psoriatic epidermis. PMID: 18174193
11. CCHCR1 is up-regulated in skin cancer and associated with EGFR expression PMID: 19551138
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亞細胞定位：

Cytoplasm. Nucleus.
組織特異性：

Found in all tissues tested, abundantly expressed in heart, liver, skeletal muscle, kidney and pancreas, and to a lesser extent in lung and placenta. Overexpressed in keratinocytes of psoriatic lesions.
數據庫鏈接：

HGNC: 13930

OMIM: 605310

KEGG: hsa:54535

STRING: 9606.ENSP00000379566

UniGene: Hs.485075

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