CARS Antibody

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) CARS Polyclonal antibody
Uniprot No.：

P49589
基因名：

CARS
別名：

Cysteine tRNA ligase antibody; Cars antibody; CysRS antibody; Cysteine--tRNA ligase antibody; Cysteinyl tRNA synthetase, cytoplasmic antibody; Cysteinyl-tRNA synthetase antibody; cytoplasmic antibody; MGC:11246 antibody; SYCC_HUMAN antibody
宿主：

Rabbit
反應種屬：

Human, Mouse
免疫原：

Recombinant Human Cysteine--tRNA ligase, cytoplasmic protein (201-500AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，CARS Antibody (CSB-PA004529LA01HU)，的標記方式是Non-conjugated。對于CARS Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA004529LB01HU	CARS Antibody, HRP conjugated	ELISA
FITC	CSB-PA004529LC01HU	CARS Antibody, FITC conjugated
Biotin	CSB-PA004529LD01HU	CARS Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, WB, IHC

推薦稀釋比：

Application	Recommended Dilution
WB	1:2000-1:5000
IHC	1:20-1:200

Protocols：

ELISA Protocol
Western Blotting (WB) Protocol
Immunohistochemistry (IHC) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

功能：

Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys).
基因功能參考文獻：
1. Four single nucleotide polymorphisms (SNPs) of CARS were significantly associated with gastric cancer risk in both the discovery stage and the validation stage PMID: 28409418
2. The risk (G and C) and non-risk (C and T) allele frequencies of the SNPs at the rs1888747 and rs739401 loci of FRMD3 and CARS, respectively, did not differ significantly between the diabetics with (case) and without (control) nephropathy (P > 0.05). PMID: 26909942
3. Loss of CARS, the cysteinyl-tRNA synthetase, suppresses ferroptosis induced by erastin, which inhibits the cystine-glutamate antiporter known as system xc(-). PMID: 26184909
4. CARS is a novel fusion partner of anaplastic lymphoma kinase in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor cases. PMID: 12112524
5. Specificity of anticodon recognition by human CysRS is higher than that of its bacterial counterparts. PMID: 17303165
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相關疾病：

A chromosomal aberration involving CARS is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with ALK.
亞細胞定位：

Cytoplasm.
蛋白家族：

Class-I aminoacyl-tRNA synthetase family
數據庫鏈接：

HGNC: 1493

OMIM: 123859

KEGG: hsa:833

STRING: 9606.ENSP00000369897

UniGene: Hs.274873

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