BLOC1S6 Antibody
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中文名稱：BLOC1S6兔多克隆抗體
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貨號：CSB-PA890745DSR2HU
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規(guī)格：￥440
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圖片：
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Western blot
All lanes: BLOC1S6 antibody at 3.33µg/ml
Lane 1: A431 whole cell lysate
Lane 2: 293T whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 20, 9 kDa
Observed band size: 20 kDa -
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA890745DSR2HU at dilution of 1:100 -
Immunoprecipitating BLOC1S6 in HEK293 whole cell lysate
Lane 1: Rabbit control IgG instead of (1µg) instead of CSB-PA890745DSR2HU in HEK293 whole cell lysate. For western blotting, a HRP-conjugated anti-rabbit IgG, specific to the non-reduced form of IgG was used as the Secondary antibody (1/50000)
Lane 2: CSB-PA890745DSR2HU (4µg) + HEK293 whole cell lysate (500µg)
Lane 3: HEK293 whole cell lysate (20µg)
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其他：
產(chǎn)品詳情
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產(chǎn)品名稱：Rabbit anti-Homo sapiens (Human) BLOC1S6 Polyclonal antibody
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Uniprot No.：
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基因名：BLOC1S6
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別名：Bloc1s6 antibody; iogenesis of lysosome-related organelles complex 1 subunit 6 antibody; PA antibody; Pallid (mouse) homolog antibody; PALLID antibody; Pallid protein antibody; Pallid protein homolog antibody; Pallidin antibody; Pallidin homolog (mouse) antibody; PLDN antibody; PLDN_HUMAN antibody; Syntaxin 13 binding protein antibody; Syntaxin 13-interacting protein antibody
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宿主：Rabbit
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反應(yīng)種屬：Human
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免疫原：Recombinant Human Biogenesis of lysosome-related organelles complex 1 subunit 6 protein (1-170AA)
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免疫原種屬：Homo sapiens (Human)
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標(biāo)記方式：Non-conjugated
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：Antigen Affinity Purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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產(chǎn)品提供形式：Liquid
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應(yīng)用范圍：ELISA, WB, IHC, IP
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推薦稀釋比：
Application Recommended Dilution WB 1:1000-1:5000 IHC 1:20-1:200 IP 1:200-1:2000 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產(chǎn)品評價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能：Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process.
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基因功能參考文獻(xiàn)：
- Results from a study on gene expression variability markers in early-stage human embryos shows that BLOC1S6 (PLDN) is a putative expression variability marker for the 3-day, 8-cell embryo stage. PMID: 26288249
- PLDN is a direct target of RUNX1 and its dysregulation is a mechanism for platelet dense granule deficiency associated with RUNX1 haplodeficiency PMID: 28075530
- Mecp2 regulates the expression of components belonging to the dysbindin interactome PMID: 23750231
- role in biogenesis of lysosome-related organelles PMID: 12191018
- no defects in the known components of pallidin-muted complex (BLOC-1)have been identified in 142 patients with HPS, suggesting that BLOC-1 function may be critical in humans. PMID: 12576321
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相關(guān)疾病：Hermansky-Pudlak syndrome 9 (HPS9)
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亞細(xì)胞定位：Cytoplasm. Membrane; Peripheral membrane protein.
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蛋白家族：BLOC1S6 family
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組織特異性：Widely expressed.
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數(shù)據(jù)庫鏈接：
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