AXIN1 Antibody, FITC conjugated

說明書

中文名稱：

AXIN1兔多克隆抗體, FITC偶聯
貨號：

CSB-PA517675LC01HU
規格：

￥880
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) AXIN1 Polyclonal antibody
Uniprot No.：

O15169
基因名：

AXIN1
別名：

AI316800 antibody; AXIN antibody; Axin 1 antibody; Axin-1 antibody; axin1 antibody; AXIN1_HUMAN antibody; Axis inhibition protein 1 antibody; Axis Inhibitor 1 antibody; Fu antibody; fused antibody; Fused; mouse; homolog of antibody; hAxin antibody; Kb antibody; Ki antibody; kinky antibody; knobbly antibody; MGC132911 antibody; MGC52315 antibody; PPP1R49 antibody; Protein Fused antibody; Protein phosphatase 1 regulatory subunit 49 antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Axin-1 protein (418-707AA)
免疫原種屬：

Homo sapiens (Human)
標記方式：

FITC
克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation.
基因功能參考文獻：
1. RNF146 exerted oncogenic role through ubiquitination of Axin1 to activate beta-catenin signaling. PMID: 29932918
2. TRIM65 exerted oncogenic activities via ubiquitylation of Axin1 to activate the beta-catenin signaling pathway. PMID: 28754688
3. coexpression of APC5 and Axin genes significantly downregulated Wnt signaling in human SW480 CRC cells and inhibited cell growth. PMID: 28731177
4. data delineate opposing roles for gamma-Pcdh isoforms in regulating Wnt signalling and identify Axin1 as a novel protein interactor of the widely-expressed gamma-Pcdh-C3 isoform PMID: 27530555
5. Genetic association of polymorphisms in AXIN1 gene with clear cell renal cell carcinoma in a Chinese population. PMID: 29053018
6. Colorectal cancer cell lines identified VACO6 cells as a carrier of a canonical PTPRK(e1)-RSPO3(e2) fusion; cell line displayed marked in vitro and in vivo sensitivity to WNT blockade by the porcupine inhibitor LGK974. Long-term treatment of VACO6 cells with LGK974 led to the emergence of a resistant population carrying two frameshift deletions of the WNT pathway inhibitor AXIN1, with consequent protein loss. PMID: 28100566
7. role in the formation of degradasomes and degradation of beta-catenin induced by the TNKSi G007-LK in colorectal cancer cells PMID: 28107521
8. RUNX1 and AXIN1 proteins are strongly correlated in ER(-) tumors as well. PMID: 28055379
9. Mutagenesis and binding studies using the bivalent TNKS binding domain of Axin1 demonstrate that only certain ankyrin repeat clusters combinations function together. SAXS analysis is consistent with a dynamic ensemble of TNKS ankyrin repeat conformations modulated by Axin1 interaction. PMID: 27594684
10. LGALS3 and AXIN1 genes affect tumor sizes and the mucinous component via Wnt/ beta-catenin pathway in the pathogenesis of colorectal cancer PMID: 26894286
11. The AXIN1 rs1805105 SNP was associated with small tumor size and early tumor stage in hepatocellular carcinoma. PMID: 26968103
12. AXIN1 is expressed in meningioma along with APC and E-cadherin PMID: 27630299
13. Data show that poly(ADP-ribose) polymerase (PARP) enzyme Tankyrase (TNKS) inhibition in colon cancer cells decreases beta-catenin signaling at the level of both Axin and APC2. PMID: 27068743
14. Cancer point mutations in the scaffold protein Axin derail Wnt signaling and promote tumor growth in vivo through a gain-of-function mechanism. PMID: 26974125
15. The pool of ADP-ribosylated Axin, which is degraded under basal conditions, increases immediately following Wnt stimulation in both Drosophila and human cells. PMID: 27138857
16. Data show that 5-hydroxytryptamine receptor (5-HT1DR) played an important role in cell invasion via Axin1/beta-catenin/matrix metalloproteinase 7 (MMP-7) pathway. PMID: 26214021
17. GSK3 acts through APC motifs R2 and B to regulate APC:Axin interactions, promoting high-throughput of betacatenin to destruction. PMID: 26393419
18. We have offered primary evidence that the T allele and T/T genotype of rs370681 polymorphisms and C/T genotype of rs1805105 polymorphisms in AXIN1 gene are more frequent in patients with cryptorchidism. PMID: 25802106
19. Higher expression of AXIN1 protein in IUGR placentae indicates a role of Wnt/beta-catenin signaling pathway in pathology of placental development. PMID: 24846767
20. This study study showed that HMGA2 was able to elicit EMT and regulate several genes which are closely related to the Wnt/beta-catenin pathway by directly binding to their promoter. PMID: 23135750
21. Significantly increased atrial septal defect risk was observed to be associated with the A allele of rs12921862 PMID: 25355064
22. suggest a novel mechanism of Wnt signaling through the dissociation of the beta-catenin destruction complex by Axin1 Thr160 modification PMID: 25735981
23. In adenomatous polyposis coli, beta-catenin phosphorylation involves Axin and the 20 amino acids of APC or APCL. PMID: 24722208
24. Which destabilize beta-catenin through stabilizing Axin. PMID: 24419084
25. Gastric neoplasia of chief cell-predominant type (GN-CCP) as a unique variant of nonaggressive tumor are characterized by nuclear beta-catenin accumulation and mutation of CTNNB1 or AXIN gene, suggesting activation of the Wnt/beta-catenin pathway. PMID: 24011952
26. The expression levels of CTNNB1, AXIN1 and APC did not correlate with the beta-catenin mutation status, which corroborates previous gene expression micro-array analyses PMID: 23525311
27. methylation status of the Axin gene may be one important factor to predict radiosensitivity of lung cancer. PMID: 23915259
28. In invasive breast cancer preserved Axin expression is associated with a more aggressive phenotype and reduced survival. PMID: 23278310
29. Our study revealed that alterations of AXIN1 were involved in hepatitis B virus-related hepatocellular carcinoma PMID: 23879168
30. X-radiation and siRNA inhibit expression of HDAC1 and HDAC2, weaken the inhibitory effect of HDAC on Axin, upregulate Axin expression and induce apoptosis of lung cancer cells PMID: 23110995
31. Abnormal hypermethylation of Axin gene is associated with lung cancer. PMID: 23192643
32. HectD1 promotes the APC-Axin interaction to negatively regulate Wnt signaling. PMID: 23277359
33. Despite the absence of AXIN1 gene mutations, the low level of Axin-1 protein in the cytoplasm probably also plays a role in tumorigenesis. PMID: 21769465
34. Phosphorylation of axin-1 by glycogen synthase kinase(GSK)-3beta accelerates the association of axin-1 with beta-catenin. PMID: 22933777
35. respiratory epithelial polygonal and cuboidal cells have distinct expression of beta-catenin, Axin, and C-myc PMID: 22614067
36. Low axin1 is associated with hepatocellular carcinoma. PMID: 22524844
37. Results demonstrate that beta-catenin is not only phosphorylated inside the APC/Axin1 destruction complex, but also ubiquinated and degraded via the proteasome, all within an intact Axin1 complex. PMID: 22682247
38. 3 synonymous alterations (p.P39P, p.D260D, p.V383V)were found in patients with ALL and one novel synonymous alteration (p.G67G) in the cohort with AML. A new g.G42525A variation was seen in intron 4-5 in 3 patients with acute leukemia. PMID: 21902576
39. Wnt/beta-catenin signaling and AXIN1 may regulate the efficacy of inhibitors of BRAF(V600E), suggesting that manipulation of the Wnt/beta-catenin pathway could be combined with BRAF inhibitors to treat melanoma PMID: 22234612
40. These results reveal an important mode of Myc activation in human breast cancer and a mechanism contributing to Myc deregulation involving unique insight into inactivation of the Axin1 tumor suppressor in breast cancer. PMID: 21808024
41. RNF146 RING-type ubiquitin E3 ligase as a positive regulator of Wnt signaling that operates with tankyrase to maintain low steady-state levels of Axin proteins PMID: 21799911
42. Axin I expression was investigated in 42 patients with glioblastoma, the most aggressive form of glial tumors. Immunostaining and image analysis revealed the quantity and localization of the protein. PMID: 21648318
43. methylation of Axin by PRMT1 may serve as a finely tuned regulation mechanism for Wnt/beta-catenin signaling. PMID: 21242974
44. axin associates with ubiquitin-specific protease 34 (USP34); results indicate USP34 controls the levels of axin and positively modulate Wnt signaling by acting downstream of beta-catenin stabilization through controlling the nuclear accumulation of axin PMID: 21383061
45. found that dominant-negative mutants of PML blocked AXIN-induced p53 activation, and that AXIN promotes PML sumoylation, a modification necessary for PML functions PMID: 21057547
46. these results support a model in which the unfolded nature of these critical scaffolding regions in Axin1 facilitates dynamic interactions with a kinase and its substrate, which in turn act upon each other. PMID: 21087614
47. Study demonstrate that the DIX domains of Dvl and Axin are expressed noticeably in a multi-cistronic system but not in a mono-cistronic system. PMID: 20846493
48. Down regulation of axin expression and up regulation of beta-catenin were detected in neuroepithelial brain tumors PMID: 19633924
49. MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway PMID: 20128690
50. Axin downregulates TCF-4 transcription via beta-catenin and independently of p53. PMID: 20122174
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相關疾病：

Hepatocellular carcinoma (HCC); Caudal duplication anomaly (CADUA)
亞細胞定位：

Cytoplasm. Nucleus. Membrane. Cell membrane.
組織特異性：

Ubiquitously expressed.
數據庫鏈接：

HGNC: 903

OMIM: 114550

KEGG: hsa:8312

STRING: 9606.ENSP00000262320

UniGene: Hs.592082

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