ATP8A2 Antibody

中文名稱：

ATP8A2兔多克隆抗體
貨號：

CSB-PA865134LA01HU
規格：

￥440
圖片：
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA865134LA01HU at dilution of 1:100

Immunofluorescent analysis of HepG2 cells using CSB-PA865134LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
其他：

產品詳情
產品評價
相關產品
靶點詳情

產品詳情

產品名稱：

Rabbit anti-Homo sapiens (Human) ATP8A2 Polyclonal antibody
Uniprot No.：

Q9NTI2
基因名：

ATP8A2
別名：

AT8A2_HUMAN antibody; ATP antibody; Atp8a2 antibody; ATPase aminophospholipid transporter class I type 8A member 2 antibody; ATPase aminophospholipid transporter like class I type 8A member 2 antibody; ATPase class I type 8A member 2 antibody; ATPase phospholipid transporting 8A2 antibody; ATPIB antibody; CAMRQ4 antibody; EC=3.6.3.1 antibody; IB antibody; ML-1 antibody; ML1 antibody; P4 ATPase flippase complex alpha subunit ATP8A2 antibody; Probable phospholipid-transporting ATPase IB antibody
宿主：

Rabbit
反應種屬：

Human
免疫原：

Recombinant Human Phospholipid-transporting ATPase IB protein (358-570AA)
免疫原種屬：

Homo sapiens (Human)

標記方式：

Non-conjugated

本頁面中的產品，ATP8A2 Antibody (CSB-PA865134LA01HU)，的標記方式是Non-conjugated。對于ATP8A2 Antibody，我們還提供其他標記。見下表：

標記方式	貨號	產品名稱	應用
HRP	CSB-PA865134LB01HU	ATP8A2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA865134LC01HU	ATP8A2 Antibody, FITC conjugated
Biotin	CSB-PA865134LD01HU	ATP8A2 Antibody, Biotin conjugated	ELISA

克隆類型：

Polyclonal
抗體亞型：

IgG
純化方式：

>95%, Protein G purified
濃度：

It differs from different batches. Please contact us to confirm it.
保存緩沖液：

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
產品提供形式：

Liquid
應用范圍：

ELISA, IHC, IF

推薦稀釋比：

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols：

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
儲存條件：

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
貨期：

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
用途：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

功能：

Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:TMEM30A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth. Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival.
基因功能參考文獻：
1. Study describes a new ATP8A2 gene mutations associated with a novel syndrome that includes encephalopathy, intellectual disability, severe hypotonia, chorea and optic atrophy. The data expand both the genetic and phenotypic spectrum associated with ATP8A2 gene mutations. PMID: 27679995
2. ATP8A2 is involved in the development of the cerebro-cerebellar structures required for posture and gait. PMID: 22892528
3. CDC50A is the beta-subunit of ATP8A2 and is crucial for the correct folding, stable expression, export from endoplasmic reticulum, and phosphatidylserine flippase activity of ATP8A2 PMID: 21454556
4. P4-ATPase Atp8a2 is a phosphatidylserine flippase in photoreceptor disc membranes PMID: 19778899
相關疾?。?/div>
Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 4 (CMARQ4)
亞細胞定位：

Membrane; Multi-pass membrane protein. Golgi apparatus. Endosome. Cell projection, cilium, photoreceptor outer segment. Cell membrane. Photoreceptor inner segment.
蛋白家族：

Cation transport ATPase (P-type) (TC 3.A.3) family, Type IV subfamily
組織特異性：

Strongly expressed in the brain, cerebellum, retina and testis.
數據庫鏈接：

HGNC: 13533

OMIM: 605870

KEGG: hsa:51761

STRING: 9606.ENSP00000371070

UniGene: Hs.444957

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